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Professor Susan Castillo's work draws on scholarship from the fields of history, literature, sociology, gender studies, political science, anthropology, and history of art. She edits Journal of American Studies (CUP), the leading publication in United States Studies on this side of the Atlantic, and she is on the Executive Boards of the International American Studies Association, the National Conference of University Professors, and the British Association for American Studies.

She has reviewed research proposals for the Arts and Humanities Research Council (AHRC), the Leverhulme Trust, the British Academy, and the Fonds zur Förderung der Wissenschaftlichen Forschung (FWF), the Austrian research funding body.

Professor Castillo's interdisciplinary work on race, gender and ethnicity is well-known on both sides of the Atlantic.

Her monograph American Literature in Context to 1865 was published by Wiley-Blackwell in July 2010.

She has also edited, with David Seed, the essay collection American Travel and Empire (Liverpool University Press, 2009).

Her monograph Colonial Encounters in New World Writing: Performing America was described by Professor Peter Hulme as, "an extraordinarily large and fascinating body of material produced in three languages over three centuries.”

Her anthology of Early American writing, The Literatures of Colonial America: An Anthology was received with similar enthusiasm by critics. Professor Richard Gray, FBA, comments, “This is that rare thing, a landmark anthology. Shifting the critical paradigms as it does, while providing a rich diversity of material, this anthology will undoubtedly be an indispensable resource for students of American literature and history."

Her edited volumes, Engendering Identities: Native American Women in Literature and Culture and Pos-Colonialismo e Identidade (Lusophone post-colonial history, sociology, literature, and popular culture) are similarly interdisciplinary, multi-lingual and wide-ranging in nature.

She has also published a book of poetry, The Candlewoman’s Trade (2003) with Diehard Press and is a practicing literary translator.