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Pharmaceutical Biophysics

Capabilities, Models, Methods

Spectroscopic techniques

  • structure determination by NMR
  • solid-state NMR
  • NMR metabolomics (liquid state and HR-MAS)
  • fluorescence (Cary Eclipse)
  • circular dichroism
  • linear dichroism
  • optical rotation 

Scattering techniques

  • dynamic light scattering
  • static light scattering
  • SANS
  • SAXS

Allied biophysical techniques

  • HPLC and size exclusion chromatography
  • rheometry
  • neutron reflectivity
  • MD simulations
  • computer modelling of drug-receptor interactions 

Biological techniques

  • membrane protein expression and purification
  • antimicrobial peptide expression and purification
  • cell culture (cytotoxicity, evaluation of DNA and siRNA delivery)
  • antibiotic MIC testing
     
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