Cell Motility and Cytoskeleton
Section Head: Professor Gareth E Jones
The coordinated migration and adhesion of cells is a prerequisite for the establishment and maintenance of multi-cellular organisms. The cell cytoskeleton provides the driving force for cell motility and adhesion. Tight regulation of cell migration and adhesion is essential for development, wound healing and immune responses, whereas deregulation contributes to the progression of various diseases including chronic inflammatory diseases and cancer metastasis.
The laboratories of the Cell Motility & Cytoskeleton Section share a common interest in the role of the cell cytoskeleton in the generation of cell polarity, cell shape, axon guidance, cell adhesion, and cell migration. Laboratories in this section analyse the signalling pathways that control the actin and microtubule cytoskeletons during the migration of cells or guidance of axons, as well as the abnormal migration of cancer cells. They also investigate the regulation of cell adhesion and polarity.
Section Members
Collaborators
Laboratories in the Cell Motility & Cytoskeleton Section have strong ties with other laboratories at King’s College London interested in cell motility and the cytoskeleton: