Wolfson CARD Blog
February 2012
This blog provides updates on the latest news from the Wolfson CARD research teams. Email your updates to Sarah Flatters.
Recent grants awarded to Wolfson CARD
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7-year Wellcome Trust Senior Investigator Award (£1.98 million) awarded to Prof. Steve McMahon
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5-year grant (£4.6 million) from National Institute for Health Research to establish the Biomedical Research Unit for Dementia awarded in part to Prof. Clive Ballard (as one of six PIs)
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5-year grant from Edmond & Lily Safra foundation awarded to Prof. Paul Francis and Prof. Clive Ballard
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2-year grant (821,000 DKK; £92k) from Lundbeck Foundation grant awarded to Dr. Marzia Malcangio
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Equipment grant (£15k) from Royal Society awarded to Dr. Sarah Flatters
Recent awards and congratulations to Wolfson scientists
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Florence Fricker, Barney Bryson, Matthew Betts, Sebastian Heinzmann, John Dawes and Eugene Boshoff on gaining their PhDs
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Juan Ramirez Rozo on gaining the Becas Francisco José de Caldas studentship
The Wolfson CARD would like to welcome
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Dr Oleg Glebov, London Law Trust Medal Fellow
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Dr Rikke Rie Hansen, research fellow, joins Dr. Marzia Malcangio funded by the Lundbeck Foundation
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Nicholas Beazley-Long, research associate, joins Dr. Sarah Flatters funded by the Wellcome Trust
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Dr. Martin Broadstock, Edmond and Lily Safra Research Fellow, joins Prof. Paul Francis and Prof. Clive Ballard
Recent publications from Wolfson CARD
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Lalli G (2012) Crucial polarity regulators in axon specification. Essays in Biochemistry - Edition on "Cell Polarity and Cancer" - In press
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Ekonomou A, Johnson M, Perry RH, Perry EK, Kalaria RN, Minger SL, Ballard CG (2011) Increased neural progenitors in individuals with cerebral small vessel disease. Neuropathol Appl Neurobiol. Oct 12 [epub]
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Johnson M, Ekonomou A, Hobbs C, Ballard CG, Perry RH, Perry EK (2011) Neurogenic marker abnormalities in the hippocampus in dementia with Lewy bodies. Hippocampus;21(10):1126-36
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Ekonomou A, Ballard CG, Pathmanaban ON, Perry RH, Perry EK, Kalaria RN, Minger SL (2011) Increased neural progenitors in vascular dementia. Neurobiol Aging;32(12):2152-61
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Graham AHD, Surguy SM, Langlois P, Bowen CR, Taylor J & Robbins J (2012) Modification of standard CMOS technology for cell-based biosensors. Biosens Bioelectron 31:458-462
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Hanney M, Prasher V, Williams N, Jones EL, Aarsland D, Corbett A, Lawrence D, Yu LM, Tyrer S, Francis PT, Johnson T, Bullock R, Ballard C (2012) Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Lancet - In press
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Lai MK, Tsang SW, Esiri MM, Francis PT, Wong PT, Chen CP (2011) Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease Psychopharmacology (Berl) 213:431-439
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Ohrfelt A, Zetterberg H, Andersson K, Persson R, Secic D, Brinkmalm G, Wallin A, Mulugeta E, Francis PT, Vanmechelen E, Aarsland D, Ballard C, Blennow K, Westman-Brinkmalm A (2011) Identification of Novel alpha-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS MethodNeurochemRes, 36:2029-2042
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Guadagna S, Bundgaard C, Jensen N, Volbracht C, Francis PT, Egebjerg J, Sotty F (2012) Memantine potentiates hippocampal theta oscillations at a therapeutic dose in anesthetized mice: A mechanistic link to its cognitive-enhancing properties Neuropharmacology - In press
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Broadstock M, Lewinsky R, Jones EL, Mitchelmore C, Howlett DR, Francis PT (2011) Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice. J Neural Transm - In press
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Williams G(2012) A searchable cross-platform gene expression database reveals connections between drug treatments and disease. BMC Genomics 13:12
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Toon A, Williams G (2012) A dynamical approach to contact distance based protein structure determination. J Mol Graph Model 32, 75-81
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Abeler-Dörner L, Swamy M, Williams G, Hayday AC, Bas A (2012) Butyrophilins: an emerging family of immune regulators Trends Immunol. 33(1):34-41
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Andersson DA, Gentry C, Alenmyr L, Killander D, Lewis SE, Andersson A, Bucher B, Galzi JL, Sterner O, Bevan S, Högestätt ED, Zygmunt PM (2011) TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol. Nat Commun.22;2:551
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James ND, Bartus K, Grist J, Bennett DLH, McMahon SB, Bradbury EJ (2011) Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages. J Neurosci 31(50):18543-55
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Hutson TH, Buchser W, Bixby J, Lemmon VP, Moon LDF (2011) Optimization of a 96-well electroporation assay for postnatal rat CNS neurons suitable for cost-effective, medium-throughput screening of plamids that promote survival or neurite outgrowth. Front. Mol. Neurosci. 4:55
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Soleman S, Yip PK, Duricki DA, Moon LDF (2012) Delayed treatment with Chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats. Brain – In press
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Jones EL, Aarsland D, Londos E, Ballard C(2012) A Pilot Study Examining Associations between DYRK1A and α-Synuclein Dementias. Neurodegener Dis. Jan 21 [Epub]
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Corbett A, Ballard C (2012) Antipsychotics and mortality in dementia. Am J Psychiatry. 169(1):7-9.
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Aarsland D, Påhlhagen S, Ballard CG, Ehrt U, Svenningsson P (2011) Depression in Parkinson disease--epidemiology, mechanisms and management. Nat Rev Neurol. 8(1):35-47.
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Corbett A, Smith J, Creese B, Ballard C (2012) Treatment of Behavioral and Psychological Symptoms of Alzheimer's Disease. Curr Treat Options Neurol. Feb 12 [Epub]
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Clarke NA, Hartmann T, Jones EL, Ballard CG, Francis PT(2011) Antipsychotic medication is associated with selective alterations in ventricular cerebrospinal fluid Aβ 40 and tau in patients with intractable unipolar depression. Int J Geriatr Psychiatry. (12):1283-91.
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Corbett A, Stevens J, Aarsland D, Day S, Moniz-Cook E, Woods R, Brooker D, Ballard C (2011) Systematic review of services providing information and/or advice to people with dementia and/or their caregivers. Int J Geriatr Psychiatry. Oct 28 [Epub]
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Ballard C, Khan Z, Clack H, Corbett A (2011) Nonpharmacological treatment of Alzheimer disease. Can J Psychiatry 56 (10):589-95.
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Ballard C, Kahn Z, Corbett A (2011) Treatment of dementia with lewy bodies and Parkinson's disease dementia. Drugs Aging. 28(10):769-77.
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Ballard C, Corbett A (2011) Screening for dementia: an opportunity for debate. Expert Rev Neurother. 11(10):1347-9.
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Husebo BS, Ballard C, Aarsland D (2011) Pain treatment of agitation in patients with dementia: a systematic review. Int J Geriatr Psychiatry. 26(10):1012-8.
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Clark AK, Grist J, Al-Kashi A, Perretti M, Malcangio M (2011) Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Arthritis Rheum. Dec 27 [Epub]
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Old EA, Malcangio M (2011) Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states. Curr Opin Pharmacol. Nov 2. [Epub]
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Meakin PJ, Harper AJ, Hamilton DL, Gallagher J, McNeilly AD, Burgess LA, Vaanholt LM, Bannon KA, Latcham J, Hussain I, Speakman JR, Howlett DR, Ashford ML (2012) Absence of BACE1 reduces body weight, protects against diet-induced obesity, and enhances insulin sensitivity Biochem J. 2012 441(1):285-96
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Segerdahl AR, Xie J, Paterson K, Ramirez JD,Tracey I, Bennett DLH (2012) Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling. Pain – In press
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Thakur M, Rahman W, Hobbs C, Dickenson AH, Bennett DLH(2012) Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis. PLoS ONE – In press