Chronic pain is a debilitating disorder that affects millions of people world-wide and has a considerable detrimental impact on quality of life. There are multiple events which can lead to chronic pain including trauma, diabetes, surgical procedures, cancer and HIV. Effective analgesic therapies are inadequate in the majority of chronic pain patients and are often associated with unpleasant side-effects. Consequently at present there is a substantial, unmet, clinical need for more effective analgesics for chronic pain patients.
The pain group is led byProfessor Stephen McMahon and Dr Marzia Malcangio
Pain, Injury and Repair of the Damaged Nervous System
Professor Steve McMahon
Plasticity of the first pain synapse laboratory
Dr Marzia Malcangio
We study neuronal and immune cell-mediated mechanisms regulating the strength of sensory neuron-dorsal horn neuron synapse in the spinal cord to reveal new targets for chronic pain treatment.
Pain caused by chemotherapy or surgery
Dr Sarah Flatters
Our research focuses on chemotherapy-induced painful peripheral neuropathies and persistent postoperative pain. Pre-clinical and clinical studies are examining the causal mechanisms and novel treatments for these chronic pain states.
Dr Andy Grant
I am investigating TRPV4 activation in chronic neuropathic and inflammatory pain, to determine mechanisms of sensitisation
Pfizer KCL Pain Lab
Dr Ramin Raouf
Mechanisms of sensory transduction and transmission
Professor Stuart Bevan
Our laboratory studies sensory transduction and transmission in peripheral sensory neurons in order to understand some of the cellular and molecular processes that underlie nociception and analgesia.
Ionic sensory transduction mechanisms
Dr David Andersson
Transient receptor potential (TRP) ion channels are essential transduction molecules that convert chemical and physical information into electrical and ionic signals. My work is focused on how TRP channels contribute to sensory neuron transduction mechanisms
Dr David Bennett
My particular interest is the understanding of neuropathic pain. To do this I employ a wide range of techniques ranging from model systems in vitro to genetic and phenotyping studies in patients.
Ion channel activity provoking pathological sensation
Dr Reggie Docherty
The regulation of ion channel activity in sensory nerves with a view to understanding how sensation is altered in pathophysiological states including pain and peripheral neuropthathies.