Larry Hench Lecture Series
Featuring Professor Deepak Vashishth.
Director of the Rensselaer Polytechnic Institute Centre for Biotechnology & Interdisciplinary Studies
Seminar title: Making Old Bones New Again: An Extracellular Matrix Approach to Bone Regenerative Medicine
Proteins are the fabric of our lives. The human body and its microbiota potentially produce millions of proteins. With time, these proteins get modified, inactivated, damaged, or under- or over- produced. Therein lie the hazards and hopes. In my lab we have identified protein modifications in bone that, with aging, diabetes, and certain long-term drug treatments, make bone brittle. Armed with that knowledge, and the mechanisms that cause such modifications, we now know how to make old bones new again. This talk will present experimental as well as computational results from our recent studies. Here animal models and in vitro systems are used to knockout and modify select collagenous and non-collagenous bone matrix proteins to determine mechanisms that are lost and/or prevent effective repair and regeneration of bone. Examples of approaches, that are effective in generating and accelerating new bone formation; and technologies, that are ripe for translation, will be presented.
Monday 14 November, 12.30 - 1.30.
Tower Lecture Theatre, Guy's Tower Wing
Director of the Rensselaer Polytechnic Institute Center for Biotechnology & Interdisciplinary Studies (CBIS), conducting breakthrough research on bones, Deepak Vashishth, PhD, is working to redefine the role of a top tier research university: one that is engaged in public and private partnerships, involved in interdisciplinary research, and providing quality education, all to drive entrepreneurial, sustainable, socially responsible scientific discovery and technological innovation.