Molecular mechanisms of epithelial invagination in ectodermal organ development.
1st Supervisor: Dr Atsushi Ohazama
2nd Supervisor: Professor Paul Sharpe.
Description of project
Many ectodermal organs (e.g. hair, tooth, mammary glands and eye) develop through epithelial-mesenchymal interaction. They share common morphological and molecular features with other ectodermal organs. Epithelial thickening and invagination is the first morphological sign in their development. In mice with null mutations of Ikka and Irf6, incisor and hair buds evaginate rather than invagination.
Aim: To understand the pathways in which these molecules participate.
Duration of project: 4 years
Contact for further information
Dr Atsushi Ohazama
Research Topic: Craniofacial Development and Stem Cell Biology
Back to the Research Projects main page.