Targeting growth factor receptor signalling for understanding the growth and metastasis of osteosarcoma
1st Supervisor: Professor Agi Grigoriadis
2nd Supervisor: Dr Karen Liu
Description of project
The molecular mechanisms underlying the transformation of osteoblasts leading to bone tumour formation are not known. This project will focus on the role of FGF signalling in regulating both the growth of osteosarcoma cells and the control of metastatic behaviour of osteosarcoma cells using both murine and human tumour models. These studies are important for understanding both the origin of these tumours in addition to providing potential molecular targets for therapy.
Duration of project: 4 years
Contact for further information:
Professor Agi Grigoriadis
Research Topic: Craniofacial Development and Stem Cell Biology
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