A fundamental question in neuroscience concerns the mechanisms by which the organizational complexity and precision of connections between cells in the nervous system is achieved. At the cellular level, this process requires the navigation of axonal processes to their appropriate target cells, the formation of synaptic contacts with postsynaptic partners and the assembly of functional synapses, specialized structures that allow the fast transmission of information. Within these areas, our research seeks (1) to dissect signalling mechanisms that control the dynamic reorganisation of the cytoskeleton within the growth cone and at the synapse; (2) to understand how different members of the Semaphorin family of axon guidance molecules affect neuronal circuit formation; (3) investigate the temporal and spatial aspect of neuronal signaling by the use of high-resolution live cell imaging.

For more information visit

www.neurosignallab.com