Publications
Publications 2013
Fucharoen, S.; Inati, A.; Siritanaratku, N.; Thein, S. L.; Wargin, W. C.; Koussa, S.; Taher, A.; Chaneim, N.; Boosalis, M.; Berenson, R.; Perrine, S. P., A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in beta-thalassaemia intermedia and HbE/beta-thalassaemia. British journal of haematology 2013, 161, (4), 587-93.Fucharoen, S.; Inati, A.; Siritanaratku, N.; Thein, S. L.; Wargin, W. C.; Koussa, S.; Taher, A.; Chaneim, N.; Boosalis, M.; Berenson, R.; Perrine, S. P., A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in beta-thalassaemia intermedia and HbE/beta-thalassaemia. British journal of haematology 2013, 161, (4), 587-93.
Gehrke, S. S.; Pinto, E. G.; Steverding, D.; Pleban, K.; Tempone, A. G.; Hider, R. C.; Wagner, G. K., Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators. Bioorganic & Medicinal Chemistry 2013, 21, (3), 805-813.
Hider, R. C.; Kong, X. L., Iron speciation in the cytosol: an overview. Dalton Transactions 2013, 42, (9), 3220-3229.
Latunde-Dada, G. O., Iron metabolism in athletes - achieving a gold standard. European Journal of Haematology 2013, 90, (1), 10-15.
Ma, Y.; Xie, Y.; Hider, R. C., A novel fluorescence method for determination of pFe(3+). Analyst 2013, 138, (1), 96-99.
Masaratana, P.; Patel, N.; Latunde-Dada, G. O.; Vaulont, S.; Simpson, R. J.; McKie, A. T., Regulation of iron metabolism in Hamp (-/-) mice in response to iron-deficient diet. European Journal of Nutrition 2013, 52, (1), 135-143.
Matak, P.; Zumerle, S.; Mastrogiannaki, M.; El Balkhi, S.; Delga, S.; Mathieu, J. R.; Canonne-Hergaux, F.; Poupon, J.; Sharp, P. A.; Vaulont, S.; Peyssonnaux, C., Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2alpha and Altered Expression of Iron Absorption Genes in Mice. PLoS One 2013, 8, (3), e59538.
Menzel, S.; Garner, C.; Rooks, H.; Spector, T. D.; Thein, S. L., HbA2 levels in normal adults are influenced by two distinct genetic mechanisms. British Journal of Haematology 2013, 160, (1), 101-105.
Milton, J. N.; Rooks, H.; Drasar, E.; McCabe, E. L.; Baldwin, C. T.; Melista, E.; Gordeuk, V. R.; Nouraie, M.; Kato, G. R.; Minniti, C.; Taylor, J.; Campbell, A.; Luchtman-Jones, L.; Rana, S.; Castro, O.; Zhang, Y. Z.; Thein, S. L.; Sebastiani, P.; Gladwin, M. T.; Steinberg, M. H.; Walk, P. I., Genetic determinants of haemolysis in sickle cell anaemia. British Journal of Haematology 2013, 161, (2), 270-278.
Xie, Y. Y.; Liu, M. S.; Hu, P. P.; Kong, X. L.; Qiu, D. H.; Xu, J. L.; Hider, R. C.; Zhou, T., Synthesis, physico-chemical properties, and antimicrobial evaluation of a new series of iron(III) hexadentate chelators. Medicinal Chemistry Research 2013, 22, (5), 2351-2359.
Zhu, C. F.; Qiu, D. H.; Kong, X. L.; Hider, R. C.; Zhou, T., Synthesis and in-vitro antimicrobial evaluation of a high-affinity iron chelator in combination with chloramphenicol. Journal of Pharmacy and Pharmacology 2013, 65, (4), 512-520.
Publications 2012
Abbate, V.; Kong, X. L.; Bansal, S. S. Photocrosslinked bovine serum albumin hydrogels with partial retention of esterase activity. Enzyme Microb Tech 2012, 50, 130-136.
Cammack, R. (2012) Continuous-wave EPR of metalloproteins and radicals in biological systems. In Encyclopedia of Biophysics (Roberts, G.C.K. ed.) Springer, New York.
Cammack, R. (2012) EPR and ENDOR of radicals and metalloproteins in biological systems. in Encyclopedia of Biophysics (Roberts, G.C.K. ed.) Springer, New York.
Cammack, R. Metals and metalloids: Iron-sulfur proteins. The Biochemist, 2012, 34, 14-17.
Chen, Y. L.; Barlow, D. J.; Kong, X. L.; Ma, Y. M.; Hider, R. C. Prediction of 3-hydroxypyridin-4-one (HPO) log K-1 values for Fe(III). Dalton T 2012, 41, 10784-10791.
Chen, Y. L.; Barlow, D. J.; Kong, X. L.; Ma, Y. M.; Hider, R. C. Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pK(a) values. Dalton T 2012, 41, 6549-6557.
Choi, J.; Masaratana, P.; Latunde-Dada, G. O.; Arno, M.; Simpson, R. J.; Mckie, A. T. Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions. J Nutr 2012, 142, 1929-1934.
Day, T. G.; Drasar, E. R.; Fulford, T.; Sharpe, C. C.; Thein, S. L. Association between hemolysis and albuminuria in adults with sickle cell anemia. Haematol-Hematol J 2012, 97, 201-205.
Drasar, E. R.; Bennett, S.; Vasavda, N.; Thein, S. L. Predictors of length of stay and time to readmission in adult patients with sickle cell disease - a single institution experience in the UK. Brit J Haematol 2012, 157, 76-76.
Drasar, E.; Vasavda, N.; Igbineweka, N.; Awogbade, M.; Allman, M.; Thein, S. L. Serum ferritin and total units transfused for assessing iron overload in adults with sickle cell disease. Brit J Haematol 2012, 157, 645-647.
Evans, R. W.; Kong, X. L.; Hider, R. C. Iron mobilization from transferrin by therapeutic iron chelating agents. BBA-Gen Subjects 2012, 1820, 282-290.
Fernandes, E. S.; Liang, L. H.; Smillie, S. J.; Kaiser, F.; Purcell, R.; Rivett, D. W.; Alam, S.; Howat, S.; Collins, H.; Thompson, S. J.; Keeble, J. E.; Riffo-Vasquez, Y.; Bruce, K. D.; Brain, S. D. TRPV1 Deletion Enhances Local Inflammation and Accelerates the Onset of Systemic Inflammatory Response Syndrome. J Immunol 2012, 188, 5741-5751.
Gandhi, S.; O'Driscoll, S.; Rashid, S.; Badle, S.; Thein, S. L.; Height, S.; Rees, D. C. Addition of hydroxyurea to transfusion programme to treat progressive cerebral vasculopathy. Brit J Haematol 2012, 157, 74-74.
Hodnett, D.; Wood, D. M.; Raja, K.; Dargan, P. I.; Shah, A. D. A healthy volunteer study to investigate trace element contamination of blood samples by stainless steel venepuncture needles. Clin Toxicol 2012, 50, 99-107.
Khanbeigi, R. A.; Kumar, A.; Sadouki, F.; Lorenz, C.; Forbes, B.; Dailey, L. A.; Collins, H. The delivered dose: Applying particokinetics to in vitro investigations of nanoparticle internalization by macrophages. J Control Release 2012, 162, 259-266.
Lomer, M. C. E.; Cook, W. B.; Jan-Mohamed, H. J. B.; Hutchinson, C.; Liu, D. Y.; Hider, R. C.; Powell, J. J. Iron requirements based upon iron absorption tests are poorly predicted by haematological indices in patients with inactive inflammatory bowel disease. Brit J Nutr 2012, 107, 1806-1811.
Ma, Y. M.; Roy, S.; Kong, X. L.; Chen, Y. L.; Liu, D. Y.; Hider, R. C. Design and Synthesis of Fluorinated Iron Chelators for Metabolic Study and Brain Uptake. Journal of Medicinal Chemistry 2012, 55, 2185-2195.
Ma, Y.; Zhou, T.; Kong, X.; Hider, R. C. Chelating Agents for the Treatment of Systemic Iron Overload. Curr Med Chem 2012, 19, 2816-2827.
Masaratana, P.; Latunde-Dada, G. O.; Patel, N.; Simpson, R. J.; Vaulont, S.; McKie, A. T. Iron metabolism in hepcidin1 knockout mice in response to phenylhydrazine-induced hemolysis. Blood Cell Mol Dis 2012, 49, 85-91.
Patel, N.; Masaratana, P.; Diaz-Castro, J.; Latunde-Dada, G. O.; Qureshi, A.; Lockyer, P.; Jacob, M.; Arno, M.; Matak, P.; Mitry, R. R.; Hughes, R. D.; Dhawan, A.; Patterson, C.; Simpson, R. J.; Mckie, A. T. BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice. Journal of Biological Chemistry 2012, 287, 4099-4106.
Pourvali, K.; Matak, P.; Latunde-Dada, G. O.; Solomou, S.; Mastrogiannaki, M.; Peyssonnaux, C.; Sharp, P. A. Basal expression of copper transporter 1 inintestinal epithelial cells is regulated by hypoxia-inducible factor 2 alpha. Febs Lett 2012, 586, 2423-2427.
Rooks, H.; Clark, B.; Best, S.; Rushton, P.; Oakley, M.; Thein, O. S.; Cuthbert, A. C.; Britland, A.; Ruf, A.; Thein, S. L. A novel 506 kb deletion causing epsilon gamma delta beta thalassemia. Blood Cell Mol Dis 2012, 49, 121-127.
Rumjon, A.; Sarafidis, P.; Brincat, S.; Musto, R.; Malyszko, J.; Bansal, S. S.; Macdougall, I. C. Serum Hemojuvelin and Hepcidin Levels in Chronic Kidney Disease. American Journal of Nephrology 2012, 35, 295-304.
Sukumaran, A.; Varghese, J.; Tamilselvan, J.; Jeyaseelan, V.; Mani, T.; Simpson, R. J.; McKie, A. T.; Jacob, M. Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. Br J Nutr 2012, 1-8.
Thein, S. L. The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia. Blood Rev 2012, 26, S35-S39.
Vasavda, N.; Gutierrez, L.; House, M. J.; Drasar, E.; St Pierre, T. G.; Thein, S. L. Renal iron load in sickle cell disease is influenced by severity of haemolysis. Brit J Haematol 2012, 157, 599-605.
Vasavda, N.; Woodley, C.; Allman, M.; Drasar, E.; Awogbade, M.; Howard, J.; Thein, S. L. Effects of co-existing alpha-thalassaemia in sickle cell disease on hydroxycarbamide therapy and circulating nucleic acids. Brit J Haematol 2012, 157, 249-252.
Vermeer, L. S.; Lan, Y.; Abbate, V.; Ruh, E.; Bui, T. T.; Wilkinson, L. J.; Kanno, T.; Jumagulova, E.; Kozlowska, J.; Patel, J.; McIntyre, C. A.; Yam, W. C.; Siu, G.; Atkinson, R. A.; Lam, J. K. W.; Bansal, S. S.; Drake, A. F.; Mitchell, G. H.; Mason, A. J. Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic alpha-Helical Peptides. Journal of Biological Chemistry 2012, 287, 34120-34133.
Woollett , B., Klose, D., Cammack, R., Janes, R.W. and Wallace, B.A. JCAMP-DX for circular dichroism spectra and metadata Pure Appl. Chem., 2012, 84, 2171–2182.
Zhao, B.; Moody, S. C.; Hider, R. C.; Lei, L.; Kelly, S. L.; Waterman, M. R.; Lamb, D. C. Structural Analysis of Cytochrome P450 105N1 Involved in the Biosynthesis of the Zincophore, Coelibactin. Int J Mol Sci 2012, 13, 8500-8513.
Zhou, T.; Ma, Y. M.; Kong, X. L.; Hider, R. C. Design of iron chelators with therapeutic application. Dalton T 2012, 41, 6371-6389.
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