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Immunology, Infection & Inflammatory Diseases

Role of epigenetic regulators in control of immunity and inflammation

Research division: Immunology, Infection & Inflammatory Disease

First supervisor: Dr Marc Dionne

Second supervisor: Dr Leonie Taams

Sponsor: BBSRC/GSK (CASE award)

Duration: 4 years

Study mode: Full time

Eligibility: Home/EU

Stipend: £17,600

Start date: 1 October 2013

Application closing date: Wednesday 17 April 2013

Reference: CMCBI-CASE-2013


Project description

This PhD project will focus on investigating the functions of epigenetic regulatory proteins in regulating immune responses and inflammation. The student will explore the in vivo biological functions of these proteins in different immune and infection contexts using loss-of-function approaches in Drosophila melanogaster. The observations in this portion of the project will then serve as the basis for more directed experiments both in flies and in primary human lymphocytes, capitalizing on local expertise in analysis of inflammation biology in humans and Drosophila (for examples, see Clark et al., Current Biology 21: 1672 (2011) and Walter et al., Arthritis and Rheumatism 65: 627 (2013)) and on the intrinsic link to GSK. The project will combine a wide range of cell, molecular, and immunological techniques, including flow cytometry, cell culture, Drosophila genetics, and epigenome analysis. The Centre for Molecular and Cellular Biology of Inflammation, located at Guy’s Campus of King’s College London, attracts students and staff from around the world. There are strong links with industry, as well as with clinical and other basic science departments across King’s, in the UK and internationally. Work within the Centre spans the full spectrum of inflammation research from basic science to clinical trials. For further details and informal inquiries, please contact Dr Marc Dionne or Dr Leonie Taams. When applying via the KCL website, please quote project code CMCBI-CASE-2013.


This project is open to home/EU candidates only.

How to apply

Applicants should apply using the King's online application form.

Please ensure in the Research Proposal section to add 'Dr Dionne' in the supervisor's 'Name' field and quote the reference ' CMCBI-CASE-2013' in the field 'brief synopsis of our research proposal'. Please also state the project title, 'Role of epigenetic regulators in control of immunity and inflammation' where requested.

When completing the application form please do the following to ensure that you apply for the right programme/studentship:

  • Under 'type of programme' choose 'Research degrees'
  • Enter 'Immunology' in the keyword box and click 'search'
  • From the list displayed select 'Immunology, Infection & Inflammatory Disease MPhil/PhD (full-time)'

Please include a copy of your CV, two references and a statement indicating why you are interested in this project with your application.

IMPORTANT Please ensure that you quote the reference CMCBI-CASE-2013 under 'research proposal' and specify Dr Dionne as the supervisor. Please also quote the reference CMCBI-CASE-2013 in the funding section under question 4d.

The deadline for applications is Wednesday 17 April 2013.

Further information

For further details and informal enquiries please contact Dr Marc Dionne or Dr Leonie Taams.

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