Unravelling the complexity of the macromolecular networks that drive cell function is arguably the most important general challenge of post-genomic biology and medicine. This issue cuts across basic discovery science to the development of new drugs and diagnostics in the commercial and clinical settings, with correspondingly massive implications for the economy and health of the UK. Conventional proteomic analyses are useful for defining overall protein expression levels, but cannot capture the spatiotemporal complexity of protein networks in living cells on the relevant distance and time-scales. We believe that optical techniques can overcome these key limitations, and have been working to develop Optical Proteomics technologies that have been strengthened by novel mathematical analyses.
Comprehensive Cancer Imaging Centre (CCIC)
The Comprehensive Cancer Imaging Centre (CCIC) is a major collaboration between King's College London and UCL, supported by funding from CRUK, EPSRC, MRC and DoH (England).
The CCIC mission is to develop novel imaging methods and applications across a wide range of technologies:
To better understand cancer at the molecular, cellular and system scale.
To enable translation of this understanding to improve diagnosis and staging, guidance and assessment of therapies and patient outcomes.