Neurodegeneration
Neurodegeneration is the collective term for the progressive loss of neuronal structure and function, that inherently leads to the death of neurons. Neurodegenerative diseases include Amyotrophic Lateral Sclerosis (Motor Neuron Disease), Alzheimer’s disease and Parkinson’s disease. Recent advances in the investigation of neurodegenerative diseases have identified similarities between these disorders at the sub-cellular level. have identified similarities between these disorders at the sub-cellular level. Our aim is to understand mechanism of major neurological disorders to design therapies by dissecting and characterising these similarities using genetic, transcriptomic and proteomic tools as well as functional studies in conjunction with unearthing common mechanisms of gene regulation, provide tremendous scope for the development of effective clinical treatments for such debilitating disorders.
The Neurodegeneration section currently has 5 group leaders.
Professor Christopher Shaw
Familial Amyotrophic Lateral Sclerosis Group
Professor Ammar Al-Chalabi
Sporadic Amyotrophic Lateral Sclerosis Group
Professor Christopher Miller
Amyotrophic Lateral Sclerosis, Alzheimer’s disease
Dr Jean-Marc Gallo
RNA processing and RNA-based therapies
Amyotrophic Lateral Sclerosis, Alzheimer’s disease
Dr Rosalie Ferner
The Neurofibromatosis and related Disorder