Wellcome Trust Case Control Consortium 3
To build further on the success of the Genome-Wide Association Studies (GWAS) approach demonstrated by the Wellcome Trust Case Control Consortium (WTCCC), the Wellcome Trust has provided support for a further round of GWA studies in January 2009.
These include 5 WTCCC-collaborative studies to be carried out in WTCCC3 and 5 independent studies, across a range of diseases. Many of the studies represent major international collaborative networks that have together assembled large sample collections.
WTCCC3 will perform genome-wide association studies in the following 4 disease conditions: primary biliary cirrhosis, anorexia nervosa, pre-eclampsia in UK subjects, and the interactions between donor and recipient DNA related to early and late renal transplant dysfunction. The WTCCC3 will also carry out a pilot in a study of the genetics of host control of HIV-1 infection. Over 40,000 samples will be analysed using the Illumina 660K chip. The WTCCC3 will utilise the 6,000 control genotypes generated by the WTCCC2.
Anorexia Nervosa - Prof. David Collier, MRC SGDP Centre
Collaborators:
Janet Treasure, Cathryn Lewis, Ulrike Schmidt, Kirsty Kiezebrink, Allan S Kaplan, Patrick F Sullivan, James Hudson, Cynthia M Bulik, Kelly Klump, Martien Kas, Eric van Furth, Margarita CT Slof-Op't Landt, Roger Adan, Andreas Karwautz, Philip Gorwood, Xavier Estivill, Mònica Gratacòs, Fernando Fernandez-Aranda, Josep M Mercader, Palmiero Monteleone, Federica Tozzi, Anna Keski-Rahkonen, Jaakko Kaprio, Anu Raevuori, Filip Rybakowski, Johannes Hebebrand, Anke Hinney, Ted Reichborn-Kjennerud, Gun Peggy Knudsen