Our research explores the cellular and molecular basis of neurodegenerative and neurodevelopmental disorders including Alzheimer's Disease, Parkinson's disease, Huntington's disease, Batten Disease, motor neuron disease, schizophrenia, depression and autism spectrum disorder. Within this brief, we focus on using stem cells and patent specific induced pluripotent stem cells.
We use these both as models to unravel transcriptional, epigenetic and signalling regulatory mechanisms responsible for formation and maintenance of neurons and astrocytes and also as transplantation tools to restore function lost in neurodegeneration and stroke.
We also use both fly and rodent models to investigate the molecular basis of learning and memory and the loss of synaptic plasticity in disorders such as Alzheimer¹s Disease.
The research areas and diseases we work on within the Department are:
Alzheimer's Disease & Other Dementias
Batten Disease & Other Lysosomal Storage Disorders
Learning & Memory
Motor Neuron Disease/Amyotrophic Lateral Sclerosis
Neurodevelopmental Disorders & Schizophrenia
Stem Cells & Neurogenesis