Show/hide main menu

News

News Highlights

Fish oils may prevent some forms of depression

Posted on 03/10/2014
By Oddman47 (Own work) [CC0], via Wikimedia Commons

A new study, led by King’s College London, has found that omega-3 fatty acids reduce the rates of depression among patients with high levels of inflammation. 

Patients with increased inflammation have a greatly increased risk of depression. The study, published in Biological Psychiatry, involved patients who were receiving medical treatment (interferon-alpha therapy) over 6 months for chronic hepatitis C. Approximately 30% of patients receiving this type of treatment become depressed, and it is a commonly-used model of inflammation-induced depression. 

Omega-3 fatty acids, more commonly known as fish oils, have a long list of health benefits, including lowering the risk of heart disease and reducing triglyceride levels. Omega-3s are of high interest to the depression field, where several studies have suggested benefits for depression and other psychiatric disorders. The two main omega-3 fatty acids in fish oil supplements are EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

In the study, 152 patients with hepatitis C were randomised to receive two weeks of treatment with EPA, DHA, or placebo. Following the two-week treatment, the patients received a 24-week course of interferon-alpha treatment and were evaluated repeatedly for depression.

The researchers found that treatment with EPA, but not DHA or placebo, decreased the incidence of interferon-alpha-induced depression in patients being treated for hepatitis C. In addition, both EPA and DHA delayed the onset of depression, and both treatments were well tolerated, with no serious side effects.

Professor Carmine Pariante, lead author of the study and Head of the Stress, Psychiatry & Immunology Laboratory at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s, says: “It is now established that increased inflammation plays a role in causing depression in at least a subgroup of patients. Our study shows that even a short course of a nutritional supplement containing one type of omega-3 fatty acid (EPA) reduces the rates of new-onset depression to 10%, as opposed to the rate of 30% we usually see in this group.”

EPA is produced naturally by the body and considered an endogenous anti-inflammatory. Previous work, also led by Professor Pariante, found that patients with low levels of endogenous EPA in the blood were at higher risk of developing depression. 

Professor Pariante adds: “We believe that this nutritional intervention restores the natural protective anti-inflammatory capabilities of the body, and thus protects patients from new-onset depression when inflammation occurs.”

This work was supported by the National Science Council, the National Health Research Institute, the China Medical University in Taiwan, National Alliance for Research on Schizophrenia and Depression, the  Royal Society Joint Research Projects for Taiwan and United Kingdom, the UK Medical Research Council and the National Institute for Health Research (NIHR) Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King's College London. 

Paper reference: Su, K. et al. “Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial” published in Biological Psychiatry doi: 10.1016/j.biopsych.2014.01.008 

For further information, please contact Seil Collins, Press Officer (IoPPN) seil.collins@kcl.ac.uk / (+44) 0207 848 5377

Image credit: By Oddman47 (Own work) [CC0], via Wikimedia Commons
Rss Feed Atom Feed

News Highlights:

News Highlights...RSS FeedAtom Feed

Experts welcome new guidance on take-home opiate antidote

Experts welcome new guidance on take-home opiate antidote

Description
Professor John Strang from the National Addiction Centre, IoPPN and SLaM, and a group of international colleagues, welcome new WHO guidance recommending that patients, families and other non-medics who may come into contact with heroin addicts should carry the drug naloxone, an antidote for opiate overdose. The authors say that while more research is vital, the move will help save lives.
Professor Til Wykes receives Equality of Opportunity Award

Professor Til Wykes receives Equality of Opportunity Award

Description
Professor Til Wykes, Vice-Dean of Psychology and Systems Sciences and Professor of Clinical Psychology and Rehabilitation at King's College London's Institute of Psychiatry, Psychology & Neuroscience (IoPPN), has been awarded the British Psychological Society (BPS)'s Award for Promoting Equality of Opportunity.
Babies' interest in human faces linked to callous and unemotional traits

Babies' interest in human faces linked to callous and unemotional traits

Description
Scientists at King's College London, the University of Manchester, and the University of Liverpool have found that an infant's preference for a person's face, rather than an object, is associated with lower levels of callous and unemotional behaviours in toddlerhood.

Share this story:

 

Follow Us

@kingscollegelon

Live Twitter feed...

@kingscollegelon
Join the conversation
Sitemap Site help Terms and conditions Privacy policy Accessibility Modern slavery statement Contact us

© 2017 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454