Professor Timothy Vyse's Group
Professor Timothy Vyse
George Koukis Professor of Molecular Medicine
Division of Genetics and Molecular Medicine
The reasons why certain individuals develop systemic lupus erythematosus (SLE) are incompletely understood, although it is known that there is a genetic contribution to disease development. Our aim is to define what genetic changes increase the risk of SLE and how this genetic influence operates. A detailed understanding of how genetic variation can predispose to SLE will increase our knowledge of some of the fundamental abnormalities that give rise to lupus.
At present, many of the drugs that are used in the treatment of lupus produce their beneficial effect by suppressing the immune system. We propose that by understanding some of the basic abnormalities (in this case genetic factors) that contribute to SLE we will be in a better position to collaborate in the development of new drugs that will have a more direct, targeted effect on the disease