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Tony Gee

Professor of PET Chemistry

140x180pxTonyGeeEmail address: antony.gee@kcl.ac.uk

PA Contact Details:
Emma Hardy
emma.hardy@kcl.ac.uk 
020 718 88366

Qualifications

BSc(Hons), PGCE, PhD

Biography

Tony Gee is Professor of PET and Radiochemistry in the Division of Imaging Sciences at King's College London and a visiting Professor at the Department of Chemistry, Imperial College London. He obtained a BSc(Hons) in Chemistry at the University of Sussex (1985), and his PhD in Radiopharmaceutical Organic Chemistry at Uppsala University, Sweden (1991). Since then he has worked as the Director of PET Chemistry at the Guy's and St Thomas' Hospitals Clinical PET centre, UMDS, London, and the Aarhus University Hospital PET Centre in Aarhus Denmark, before moving to GlaxoSmithKline to spearhead the use of PET imaging in drug discovery and development before moving to his current position at King's College.

Research interests

A number of very active research projects are in progress including the development of rapid labelling synthetic techniques with short-lived positron-emitting radionuclides, small molecule-protein / small molecule-membrane interactions, the design of PET imaging probes, and the understanding of in vivo pharmacology.

Group members

  • Julia Blower – PhD student working on development of metabolic 11C-labelled probes for PET imaging of Glutamatergic and GABAergic function.
  • Abdul Karim Haji Dheere - MRes working on development of 11C-CO2 chemistries and application to Glutamatergic and  GABAergic receptor function.
  • Kam Kahlon - Radiochemistry Laboratory Manager 
  • Carmine Marzano - Lead Radiochemist 
  • Ray Khan - Senior Production radiochemist 
  • Neria Ossoulyan - Junior Production Radiochemist  
  • Phil Halstead - Cyclotron Engineer 
  • Mick Kelley - Cyclotron Engineer
  • Maite Jauregui-osoro - previously EPSRC Early Career fellow working on inorganic nanoparticles for pretargeted radionuclide delivery for cancer imaging and therapy, now regulatory affairs specialist funded by the King's and GSTT Biomedical Research Centre working on the translation of novel contrast agents in human use.
  • Maggie Cooper - Postdoctoral scientist and radiopharmacist, funded by the CRUK/EPSRC Cancer Imaging Centre on radiolabelling methodology for biomolecules and regulatory affairs to support clinical translation of new imaging agents.
  • Karen Shaw - Postdoctoral associate managing preclinical MRI and radioisotope supply for research.
  • Enrico Fantoni - PhD student conducting a research project regarding the in vivo imaging of proteins involved in the amyloid cascade, leading to phosphosrylation of tau.  The project aims at developing and evaluating in vivo a number of radiotracers targeting proteins related to Glycogen Synthase Kinase-3, a key player in the generation of hyperphosphorylated tau and in the onset and progression of Alzheimer's disease.
  • Julia Bagunya Torres - PhD student working on a project to visualize disturbed copper metabolism in Alzheimer's disease using PET imaging with copper Radioisotopes (mainly Copper-64) in animal models (TASTPM mice) for a later application in to human subjects. 
  • Robin Fortt - Postdoctoral scientist funded by the Biomedical Research Centre at King’s and GSTT, working on clinical translation of novel chemistry for PET applications in humans.  Primary focus on the development of robust scaled-up radiolabelling methods and synthetic strategies for the production of a range of novel labelled materials labelled with a variety of radioistopes for PET, SPECT and radionuclide therapy including; F-18, C-11, and N-13.
  • Chloe Child - Postdoctoral research associate funded by the British Heart Foundation, working on implementing the radiosynthesis of [11C]rolipram and using this radiotracer to measure cAMP levels in the heart. The main aim of the research is to determine if there is a relationship between increased levels of cAMP and [11C]rolipram binding to PDE4 in the heart observed using various techniques including tissue autoradiography and isolate perfused heart models. Other areas of interest include using [3H]rolipram and fluorine-18 radiolabelled peptides to measure PDE4 in heart tissue sections.
  • MRes Radiopharmaceutics
  • MSc Radiopharmaceutics

NHS liaison and relationship

  • Clinical PET centre
  • Director of PET Radiochemistry

 

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