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Professor Maddy Parsons

 maddy-p

Professor of Cell Biology

Director of Nikon Imaging Centre@King's

Email: maddy.parsons@kcl.ac.uk
Tel: +44 (0) 20 7848 8164
Fax: +44 (0) 20 7848 6435

Education and training

  • Sep 2015 - present: Professor of Cell Biology
  • Jan 2012 - present: Director, Nikon Imaging Centre@King's
  • Oct 2013 - Aug 2015: Reader in Cell Biology
  • Oct 2005 - Oct 2013: Royal Society University Research Fellow, Randall Division of Cell and Molecular Biophysics, King’s College London

Postdoctoral:

Aug 2004 - Sep 2005: Intermediate Research Fellow, King’s College London
June 2003 - July 2004: Senior Postdoctoral Researcher, Randall Division of Cell and Molecular Biophysics, King’s College London
April 2000 - May 2003: Postdoctoral Researcher, Cancer Research UK Laboratories, St Thomas Hospital, London

Postgraduate: PhD in Biochemistry, Dept. of Medicine, University College London; Awarded April 2000.

Undergraduate: BSc. (hons) in Biology, Second Class, Upper Division,University of Bath; Awarded July 1996

Selected Recent Publications

2016

  • Nicholas NS, Pipili A, Ameer-Beg SM, Geh JLC, Healy C, MacKenzie Ross AD, Parsons M, Nestle FO, Lacy KE, Wells CM. PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells. Oncotarget. 2016. In press.
  • Díaz-AlonsoJ, de Salas-Quiroga A, Garcez PP, Parsons M, Andradas C, Paraíso-Luna J, García-Rincón D, Sánchez C, Guillemot F, Guzmán M, Galve-Roperh I. Loss of cannabinoid CB1 receptors induces cortical migration malformations and increases seizure susceptibility. Cerebral Cortex 2016. In press.
  • Tregardh J, Schneiete J, Parsons M, McConnell G. A femtosecond Raman generator for long wavelength two-photon and third harmonic generation imaging. APL Photonics. 2016. In Press.
  • Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Grien C, Pfisterer K, Tootle T, Charras G, Gundersen GG, Parsons M. Fascin regulates nuclear movement and deformation in migrating cells. Dev Cell. 2016. Aug 22;38(4):371-83
  • Tregardh J, Murtagh M, Robb G, Parsons M, Lin J, Spence D, McConnell G. Two-color, two-photon imaging at long excitation wavelengths using a diamond Raman laser. Microscopy and Microanalysis. 2016. Aug; 5:1-5.
  • Takeichi T, Liu L, Abdul-Wahab A, McMillan JR, Stone KL, Akiyama M, Simpson MA, Parsons M, Mellerio JE, McGrath JA. Large intragenic KRT1 deletion underlying atypical autosomal dominant keratinopathic ichthyosis. J Invest Dermatol. 2016. pii: S0022-202X(16)31367-7. doi: 10.1016/j.jid.2016.06.016
  • Zhang G, Begum R, Gu Y, Chen H, Gao X, McGrath JA, Song B* Parsons M*. Kindlin-1 regulates keratinocyte electrotaxis. J Invest Dermatol. 2016. pii: S0022-202X(16)32105-4. doi: 10.1016/j.jid.2016.05.129.
  • King S, Asokan S, Haynes E, Zimmerman S, Rotty J, Alb J, Tagliatela A, Blake D, Lebedeva I, Marston D, Johnson H, Parsons M, Sharpless N, Kuhlman B, Haugh J, Bear J. Lamellipodia are critical for haptotactic sensing and response. J Cell Sci. 2016. pii: jcs.184507
  • Morton PE, Hicks A, Ortiz-Zapater E, Raghaven S, Pike R, Noble A, Woodfin A, Jenkins G, Rayner E, Santis G, Parsons M. TNFa promotes CAR-dependent migrations of leukocytes across epithelial monolayers. Sci Reps. 2016. 19;6:26321
  • Yip YY, Pernigo S, Sanger A, Xu M, Parsons M, Steiner R, Dodding M. The light chains of Kinesin-1 are autoinhibited. PNAS. 2016. Mar 1;113(9):2418-23
  • Santos C, Hafstad A, Beretta M, Zhang M, Molenaar C, Kopec J, Fotinou D, Murray T, Cobb AM, Silva MZ, Martin D, Anilkumar N, Schröder K, Shanahan CM, Brewer AC, Brandes R, Blanc E, Parsons M, Belousov V, Cammack R, Hider R, Steiner R, Shah AM. Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling. EMBO J. 2016. 35(3):319-34. 

2015

  • Levitt J, Morton PE, Fruhwirth G, Santis G, Parsons M, Suhling K. F3 microscopy: Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells. Biomed Optics Exp. 2015. 8;6(10):3842-54.
  • Defranceschi N, Peuhu E, Parsons M, Rissanen S, Vattulainen I, Masalm I, Ivaska J, Pouwels J. Mutually exclusive roles of SHARPIN in integrin inactivation and NF-kB signaling. PLoS ONE. 2015. 10(11):e0143423.
  • Villari G, Jayo A, Zanet J, Fitch B, Serrels B, Frame M, StramerB, Goult BT, Parsons M. A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration. J Cell Sci. 2015. 128(24):4601-14
  • Scarpa E, Szabo A, Bibonne A, Theveneau E, Parsons M, Mayor R. Cadherin switch during EMT in neural crest cells leads to contact inhibition of locomotion via repolarization of forces Dev Cell. 2015. 34(4):421-34. 
  • Groen C, Jayo A, Parsons M, Tootle T. New cellular sites of prostaglandin regulated Fascin activity: the nucleus and nuclear periphery. Mol Biol Cell. 2015. Mar 25. pii: mbc.E14-09-1384.
  • CarraraG, SaraivaS, Parsons M, ByrneB, Prole DL, Taylor CW, Smith GL. Golgi Anti-Apoptotic Proteins are Highly Conserved Ion Channel that Affect Apoptosis and Cell Migration. J Biol Chem. 2015. May 1;290(18):11785-801. doi: 10.1074/jbc.M115.637306
  • Simpson MA, Bradlet WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ. Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase. J Biol Chem. 2015. Feb 18. pii: jbc.M115.638874 Malboubi M, Jayo A, Parsons M, Charras G. An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments. Micro Eng. 2015. In Press.
  • Rzeniewicz K, Newe A, Rey-Gallardo A, Davies J, Holt MR, Patel A, Charras GT, Stramer B, Molenaar C, Tedder TF, Parsons M, Ivetic A. L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity. PNAS. 2015. Mar9 pii: 201417100. 
  • Klapholtz B, Herbert SL, Wellmann J, Johnson RA, Parsons M, Brown NH. Alternative mechanisms for talin to mediate integrin function. Curr Biol. 2015. Mar 4. pii: S0960-9822(15)00075-5. doi: 10.1016/j.cub.2015.01.043
  • Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Molejon Garcia A, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW ADAM8 as a drug target in Pancreatic Cancer. Nature Comms, 2015. Jan 28;6:6175. doi: 10.1038/ncomms7175

2014

  • Martin-Villar E, Borda-d´Agua B, Carrasco-Ramirez P, Renart J, Parsons M, Quintanilla M, Jones GE. Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability. Oncogene. 2014. doi: 10.1038/onc.2014.388
  • Poland SP, Krstajić N, Coelho S, Tyndall D, Walker RJ, Devauges V, Morton PE, Nicholas NS, Richardson J, Day-Uei Li D, Suhling K, Wells CM, Parsons M, Henderson RK, Ameer-Beg SM. Time-resolved multifocal multiphoton microscope for high speed FRET imaging in vivo. Optics Letters 2014. 39 (20), 5961–5964.
  • Petrof G, Nanda A, Howden J, Takeichi T, McMillan JR, Aristodemou S, Ozoemena L, Liu L, South AP, Pourreyron C, Dafou D, Proudfoot L, Al-Ajmi H, Akiyama M, McClean WHI, Simpson M, Parsons M*, McGrath JA*. Mutations in the Grainyhead-like 2 transcription factor result in an autosomal recessive ectodermal dysplasia syndrome. Am J Hum Genet 2014. 95(3):308-14.
  • Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, Kable A, Mayor R. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. J Cell Biol. 2014. Jul 7;206(1):113-127
  • CampbellP, Morton P, Takeichi T, Salam A, Roberts N, Proudfoot LE, Mellerio JE, Aminu K, Wellington C, Patil SN, Akiyama M, Liu L, McMillan JR, Aristodemou S, Ishida-Yamamoto A, Abdul-Wahab A, Petrof G, Fong K, Harnchoowong S, Stone K, Harper JI, McLean WHI, Simpson MA, Parsons M* and McGrath JA*. Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR. J Invest Dermatol. 2014. doi: 10.1038/jid.2014.164
  • Azzarelli R, Pacary E, Garg R, Garcez P, van den Berg D, Riou P, Ridley AJ, Friedel RH, Parsons M, Guillemot F. An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. 2014. Nature Comms. 5:3405. doi: 10.1038/ncomms4405
  • Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg A, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO Mol Med. 2014. 1;6(2):278-94. doi: 10.1002/emmm.201303373
  • Liu L, Mellerio JE, Martinez AE, McMillan JR,Aristodemou S,ParsonsM, McGrath JA. Mutations in EXPH5 result in autosomal recessive inherited skin fragility. 2014. Br J Dermatol. DOI 10.1111/bjd.12723
  • Salinas S, Zussy C, Loustalot F, Henaff D, Menendez G, Morton PE, Parsons M, Schiavo G, and Kremer E. Disruption of the coxsackievirus and adenovirus receptor- homodimeric interaction triggers lipid microdomain and dynamin-dependent endocytosis and lysosomal targeting. 2014. J Biol Chem.289(2):680-95. doi: 10.1074/jbc.M113.518365.

2013:

  • Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barille-Nion S, Georgakoudi I, Dagg A, McDermott EW, Duffy MJ, McGowan PM, Scholmann U, Parsons M, Bartsch JW, Sonesheim GE. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. 2013. EMBO Mol Med. In press.
  • Liu L, Mellerio JE, Martinez AE, McMillan JR, Aristodemou S, Parsons M, McGrath JA. Mutations in EXPH5 result in autosomal recessive inhertied skin fragility. 2013. Br J Dermatol. In press.
  • Salinas S, Zussy C, Loustalot F, Henaff D, Menendez G, Morton PE, Parsons M, Schiavo G, Kremer E. Disruption of coxsackievirus and adenovirus receptor homodimeric interaction triggers lipid microdomian and dynamic-dependent endocytosis and lysosomeal targeting. 2013. J Biol Chem. In press.
  • Brahme NN, Harburger DS, Stewart R, Ranghaven S, Kemp-O'Brien K, Parsons M, Calderwood DA. Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localisation and recruitment. 2013. J Biol Chem. In Press.
  • Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, Parsons M, Kashef J, Linker C, Mayor RA. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. 2013. Development. In press.
  • Morton P, Hicks A, Nastos T, Santis G, Parsons M. CAR regulates epithelial junction stability via control of E-cadherin traffic. 2013. Sci Reps. Oct 7; 3; 2889. doi: 10.1038/sreps02889
  • Michael M, Begum R, Fong K, Pourreyrone C, South AP, McGrath JA, Parsons M. BPAG1-e restricts keratinocyte migration through control of adhesion stability. 2013 J Invest Dermatol. doi: 10:1038/jid.2013.382
  • Costa P, Scales TME, Ivaska J, Parsons M. Integrin specific regulation of Focal Adhesion Kinase and RhoA regulates membrane protrusion and invasion.2013.PLoS ONE. In press.
  • Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ. Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN. 2013. PLoS ONE. 8(8), e71957.
  • Saraiva N, Prole, D, Carra G, Johnson BF, Taylor CW, Parsons M*, Smith GL*. Human GAAP regulates cell migration and focal adhesion dynamics via calpain activation. 2013 J Cell Biol. 202(4); 699-713 .
  • Sonego M, Gajendra S, Parsons M, Ma Y, Hobbs C, Zentar MP, Williams G, Machesky LM, Doherty P, Lalli G.Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain. 2013. J Neurosci33(30); 12171-85 .
  • Novitskaya V, Romanska H, Kordek R, Potemski P, Kusinska R, Parsons M, Odintsova E, Berditchevski F. Integrin α3β1 regulates regulates responses of breast cancer cells to Herceptin. Oncogene. 2013. Idoi: 10.1038/ onc. 2013.231
  • Kostourou V, Ramjaun A, Lechertier T, Jones DT, Baker M, Birdsey G, Reynolds LE, Tavora B, Robinson S, Parsons M, Randi A, Hart IR, Hodivala-Dilke KM. FAK-heterozygous mice display enhanced pathological angiogenesis. Nature Comms. 2013. 4; 2020
2012
  • Kemp-O’Brien K and Parsons M. Using FRET to analyse signals controlling cell adhesion and migration. J Microscopy. 2012. doi: 10.1111/j.1365-2818. 2012.03686
  • McGrath JA, Stone KL, Begum R, Simpson MJ, Dopping-Hepenstal PJ, Liu L, McMillan JR, South AP, Pourreyron P, McLean I, Martinez A, Mellerio JE, Parsons M. Germline mutation in the EXPH5 gene implicates the Rab27B effector protein Slac2-b (exophilin- 5) in inherited skin fragility. Am J Hum Gen. 2012. 91(6); 1115-21
  • Jayo A, Parsons M, Adams JC. A novel Rho-dependent pathway that drives interaction of fascin-1 with LIM kinase1/2 to promote fascin-1/actin binding and filopodia stability. BMC Biol. 2012. 10;10:72.
  • Scales TME, Jayo A, Obara B, Holt MR, Hotchin, NA, Berditchevski F, Parsons M. a3b1 integrins regulate CD151complex assembly and membrane dynamics in carcinoma cells within 3D environments. Oncogene. 2012. doi: 10.1038/onc.2012.41
  • Maiuri P, Terriac E, Paul-Gilloteaux P, et al. The First World Cell Race. Curr Biol. 2012. 11;22(17):R673-5.
  • Jayo A, Parsons M. Imaging of cell adhesion events in 3D matrix environments. Eur J Cell Biol. 2012. Jun 16. [Epub ahead of print].
  • Zanet J, Jayo A, Millard T, Plaza S, Parsons M, Stramer B. An actin-bundling independent role for fascin in filopodia. J Cell Biol. 2012. 197(4); 477-86.  
  • Locke FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA. Differential Regulation of Adhesion Complex Turnover by ROCK1 and ROCK2. PLoS ONE. 2012. 7(2):e31423
  • Birdsey GM, Dryden NH, Shah AV, Hannah R, Hall MD, Haskard DO, Parsons M,Mason JC, Zvelebil M, Gottgens B, Ridley AJ, and Randi AM. The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis. Blood 2012. 119(3):894-903
2011
  • Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page K, Parsons M, Lambris J, Mayor R. Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell. 2011. Dec 13;21(6):1026-37 
  • Lai-Cheong JE, Moss C, Parsons M, Almaani N, McGrath JA. Revertant mosaicism in Kindler Syndrome. J Invest Dermatol.2011. doi: 10.1038/jid.2011.352
  • Liu L, Dopping-Hepenstal PJ, Lovell PA, Michael M, Horn H, Fong F, Lai-Cheong JE, Mellerio JE, Parsons M, McGrath JA. Autosomal Recessive Epidermolysis Bullosa Simplex Due to Loss ofBPAG1-e Expression. J Invest Dermatol.2011. 10.1038/jid.2011.379
  • Rantala JK, Pouwels J, Pellinen T, Veltel S,Laasola P,Potter CS, Duffy T,Sundberg JP, Kallioniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J. SHARPIN is an endogenous inhibitor of beta1 integrin activation. Nat Cell Biol.  2011. 13(11):1315-24 
  • Hussain F, Morton PE, Snippe M, Sullivan J, Farmer C, Martin-Fernandez ML, Parsons M, Santis G. CAR modulates E-cadherin dynamics in the presence of adenovirus type 5. PLoS ONE.2011 6(8):e23056.
  • Morton PE and Parsons M. Dissecting cell adhesion architecture using advanced imaging techniques.Cell Adh Migrn. 2011. 5;4.

  • Wells CM and Parsons M (Eds) Cell Migration – development methods and protocols. Methods Mol Biol series 2011.

  • Morton PE and Parsons M.Measuring FRET using time-resolved FLIM. Methods Mol Biol. 2011. 769:403-413.

  • Scales TME and Parsons M. Spatial and temporal regulation of integrin signalling during cell migration. Curr Opin Cell Biol. 2011. 20Jun: e-pub ahead of print.

  • King SJ and Parsons M. Imaging cell within 3D cell-derived matrix. Methods Mol Biol. 2011. 769:53-64.

  • King SJ, Worth DC, Scales TME, Monypenny J, Jones GE and Parsons M. beta1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. EMBO J. 2011;30(9):1705-18.

  • Pacary E, Heng J, Azzarelli R, Riou P, Castro D, Lebel-Potter M, Parras C, Bell DM, Ridley AJ, Parsons M, Guillemot F. Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signalling. Neuron. 2011.69(6):1069-84.
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