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Eggert Group

Professor Ulrike Eggert

RikiEggert(190x173)

Professor in Chemical Biology

Department of Chemistry

Randall Division of Cell and Molecular Biophysics

Email: ulrike.eggert@kcl.ac.uk

Room 2.36D, 2nd floor
New Hunt’s House
Guy’s Campus
London SE1 1UL

Tel: +44 (0) 20 7848 8463
Fax: +44 (0) 20 7848 6435

Education and career

    • 2015- present Professor of Chemical Biology, Randall Division of Cell and Molecular Biophysics and Department of Chemistry, King’s College London
    • 2011- 2015 Senior Lecturer, then Reader in Chemical Biology, King’s College London
    • 2006-2011 Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
    • 2001-2006 Helen Hay Whitney Foundation postdoctoral fellow, Harvard Medical School, supervisor: Professor Tim Mitchison
    • 2001 PhD in Chemistry, Princeton University, supervisor: Professor Dan Kahne
    • 1995 MChem (undergraduate degree), University of Oxford

Publications

  • Lipids in cell biology – how can we understand them better?” E. Muro*, G.E. Atilla-Gokcumen*, U.S. Eggert MBoC, MBoC, 2014 Jun 15;25(12):1819-23. doi: 10.1091/mbc.E13-09-0516.
  • Dividing cells regulate their lipid composition and localization.
    G. E. Atilla-Gokcumen*, E. Muro*, J. Relat-Goberna, S. Sasse, A. Bedigian, M. L. Coughlin, S. Garcia-Manyes, U. S. Eggert, Cell 2014; Jan 30;156(3):428-39. doi: 10.1016/j.cell.2013.12.015.
  • The why and how of phenotypic small-molecule screens.
    U.S. Eggert, Nature Chemical Biology. 2013 Apr;9(4):206-9. doi: 10.1038/nchembio.1206
  • Non-traditional roles of G protein-coupled receptors in basic cell biology.
    X. Zhang X, U.S. Eggert, Mol Biosyst. 2013 Apr 5;9(4):586-95. doi: 10.1039/c2mb25429h
  • G-protein-coupled receptors participate in cytokinesis.
    X. Zhang, A. V. Bedigian, W. Wang, U. S. Eggert, Cytoskeleton "Cytokinesis - special issue honoring Dr. Ray Rappaport”, 2012 Oct;69(10):810-8. doi: 10.1002/cm.21055
  • The natural product cucurbitacin inhibits depolymerization of actin filaments. P.M. Sörensen, R.E. Iacob, M. Fritzsche, J.R. Engen, W.M. Brieher, G. Charras and U.S. Eggert, ACS Chem Biol. 2012 Sep 21;7(9):1502-8. doi: 10.1021/cb300254s
  • Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI. X. Zhang, W. Wang, A.V. Bedigian, M.L. Coughlin, T.J. Mitchison and U.S. Eggert, Proc Natl Acad Sci USA. 2012 Jul 31;109(31):12485-90. doi: 10.1073/pnas.1207821109
  • The chromosomal passenger complex activates Polo kinase at centromeres. M. Carmena, X. Pinson, M. Platani, Z. Salloum, Z. Xu, A. Clark, F. Macisaac, H. Ogawa, U. Eggert, D.M. Glover, V. Archambault, W.C. Earnshaw, PLoS Biol. 2012 Jan;10(1):e1001250. doi: 10.1371/journal.pbio.1001250
  • Ulrike Eggert: big things from small molecules. Interview by Caitlin Sedwick. U.S. Eggert, J Cell Biol. 2011 Aug 8;194(3):352-3. doi: 10.1083/jcb.1943pi
  • Inhibition of long-chain glycosphingolipid biosynthesis induces cytokinesis failure. G.E. Atilla-Gokcumen, S. Sasse, A.V. Bedigian and U.S. Eggert, J. Am. Chem Soc., 2011 Jul 6;133(26):10010-3. doi: 10.1021/ja202804b
  • Small Molecule Probes of Cellular Pathways and Networks. A.B. Castoreno and U.S. Eggert, ACS Chemical Biology 2011 Jan 21;6(1):86-94. doi: 10.1021/cb1002976
  • 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Q. Zhou, Y. Kee, C.C. Poirier, C. Jelinek, J. Osborne, S. Divi, A. Surcel, M.E. Will, U.S. Eggert, A. Müller-Taubenberger, P.A. Iglesias, R.J. Cotter, D.N. Robinson, Current Biology, 2010 Nov 9;20(21):1881-9. doi: 10.1016/j.cub.2010.09.048
  • Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. Y. Smurnyy, A. Toms, G.R. Hickson, M.J. Eck and U.S. Eggert, ACS Chemical Biology, 2010 Nov 19;5(11):1015-20. doi: 10.1021/cb1001685
  • Small molecules that target the Rho pathway differentially perturb key cytokinesis proteins. A.B. Castoreno, Y. Smurnyy, A.D. Torres, M.S. Vokes, T.R. Jones, A.E. Carpenter, U.S. Eggert, Nature Chemical Biology, 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363
  • Making the cut: the chemical biology of cytokinesis. G.E. Atilla-Gokcumen,* A.B. Castoreno,* S. Sasse, U.S. Eggert, ACS Chemical Biology, 2010 Jan 15;5(1):79-90. doi: 10.1021/cb900256m
  • Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. T.R. Jones, A.E. Carpenter, M.R. Lamprecht, J. Moffat, S.J. Silver, J.K. Grenier, A.B. Castoreno, U.S. Eggert, D.E. Root, P. Golland, D.M. Sabatini, Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1826-31. doi: 10.1073/pnas.0808843106
  • Actin-Aggregating Cucurbitacins from Physocarpus capitatus. K.N. Maloney, M. Fujita, U.S. Eggert, F.C. Schroeder, C.M. Field, T.J. Mitchison, J. Clardy, J Nat Prod. 2008 Oct 30
  • Drugs in action. U.S. Eggert and G. Superti-Furga, Nature Chemical Biology 2008, 4, 7-11.
  • Drug-target identification in Drosophila cells: combining high-throughput RNAi and small-molecule screens. N. Perrimon, A. Friedman, B. Mathey-Prevot, U.S. Eggert, Drug Discovery Today. 2007, 12, 28-33.
  • Small Molecule Screening by Imaging. U.S. Eggert and T.J. Mitchison, Curr. Op. Chem. Biol. 2006, 10, 232-237
  • Animal Cytokinesis: From Parts Lists to Mechanisms. U.S. Eggert, T.J. Mitchison and C.M. Field, Ann. Rev. Biochem. 2006, 75, 543-566
  • Small molecules in an RNAi world. U.S. Eggert, C.M. Field and T.J. Mitchison, Mol. BioSyst., 2006, 2, 93-96
  • Parallel Chemical and Genome-wide RNAi Screens Identify Cytokinesis Inhibitors and Targets. U.S. Eggert, A.A. Kiger, C. Richter, Z.E. Perlman, N. Perrimon, T.J. Mitchison and C.M. Field, PLoS Biology, 2004, 2, e379
  • Structural Requirements for VanA Activity of Vancomycin Analogues. Z. Chen, U.S. Eggert, S.D. Dong, S.J. Shaw, B.Y. Sun, J.V. LaTour and D. Kahne, Tetrahedron 2002, 58, 6585-6594
  • The Structural Basis for Induction of VanB Resistance. S.D. Dong, M. Oberthur, H.C. Losey, J.W. Anderson, U.S. Eggert, M.W. Peczuh, C.T. Walsh, D. Kahne, J. Am. Chem. Soc. 2002, 124, 9064-9065
  • A Genetic Basis to Understanding Activity Differences Between Vancomycin and Glycolipid Derivatives of Vancomycin. U.S. Eggert, N. Ruiz, A.A. Branstrom, B.V. Falcone, R.C. Goldman, T. J. Silhavy and D. Kahne, Science 2001, 294, 361-364
  • Tandem Action of Glycosyltransferases in the Maturation of Vancomycin and Teicoplanin Aglycones: Novel Glycopeptides. H.C. Losey, M.W. Peczuh, Z. Chen, U.S. Eggert, S.D. Dong, I. Pelczer, D. Kahne, C.T. Walsh, Biochemistry 2001, 40, 4745-4755.
  • Hybrid Glycolipid Antibiotics. B. Sun, Z. Chen, U.S. Eggert, J.V. LaTour, S.J. Shaw and D. Kahne, J. Am. Chem. Soc. 2001 123 (50):12722-12723

* equal contribution

 

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