Cell division is an important fundamental biological process required for life, growth and development. It requires the coordinated action of many different cellular machines and regulators. Although we have known that cells divide since the concept of the cell was first established, there are many outstanding mechanistic questions, especially in cytokinesis, the final step where cells physically divide. Cytokinesis has been difficult to study because it is a complex, rapid and dynamic process. Many key proteins also perform important functions earlier in the cell cycle, which makes it challenging to investigate their roles during cytokinesis using traditional techniques. New approaches are therefore needed to overcome these barriers to deeper understanding, one of which is to develop probes that act rapidly and with high temporal control.
Our group uses chemical and cell biology approaches to study cytokinesis at the process, pathway, protein and metabolite levels.
Our research is funded by the Wellcome Trust and the European Research Council.
Our lab is in the Department of Chemistry and the Randall Division of Cell and Molecular Biophysics.
Super resolution image of lipid markers in a dividing HeLa cell. Inset: midbody region (Cholera toxin to visualise GM1 - green, ceramide antibody -red)