Indices of Tolerance
This study was a multinational European project financed by the European Commission within the Fifth Framework Programme and the Immune Tolerance Network. We aimed to develop bioassays and biomarkers that target the immune system to try an identify immunological tolerance in transplantation. To define a set of tests that can be used to predict the presence of transplantation tolerance in kidney transplant patients could allow the informed and safe withdrawal of immunosuppression in the long term.
The follow on study was then funded within the Sixth Framework Programme: Reprogramming the Immune System for Establishment of Tolerance (RISET).
IMMUNE TOLERANCE NETWORK
The Immune Tolerance Network is an international clinical research consortium founded by the National Institutes of Health, whose mission is to accelerate the clinical development of immune tolerance therapies through a unique development model.
Genetic Analysis and Monitoring of Biomarkers of Immunological Tolerance
Kidney transplantation is the main treatment for children and adults with kidney failure and leads to substantial improvements in the quality of life for our patients. The major problems that transplant patients face are rejection, increased risk of cancer, severe cardiovascular disease and complications of the drugs used to damp down the immune response to prevent rejection; children are particularly affected by these drugs.
In this study we are trying to identify markers that will help us improve treatment in transplant recipients.