Professor Noelle’s research is focused on the cellular and molecular basis for the impact of Vitamin A on immunity. His studies to date have focused on the importance of Vitamin A, and its metabolite retinoic acid (RA), in host resistance to infectious disease.
Up to 10 million malnourished children a year are at increased risk of complications and death from infectious diseases due to deficiency in Vitamin A. Professor Noelle's laboratory has also recently identified a new negative checkpoint regulator for the immune system, called VISTA, that is an exciting, new target in the treatment of a variety of immune related diseases, like cancer and autoimmunity. This target is currently being developed for human therapy.