Current projects and collaborators
As Principal Investigator:
Pneumococcal protection of the aged by IgM B cells
In collaboration with Dr Jo Spencer, Dr Jonathan Edgeworth, Prof David Kipling (University of Cardiff), and Dr Helen Baxendale (Institute of Child Health)
Human immune memory and vaccine responses: High throughput analyses of antibody repertoire and function
In collaboration with Dr Antonio Lanzavecchia (Bellinzona Switzerland), Prof Ramit Mehr (Bar-Ilan Israel) and Dr Juan Carlos Almagro (Centocor, USA)
B cell homeostasis and selection in ageing
In collaboration with Prof Andrew Cope and Prof Michael Cancro (Penn, USA)
Signatures and mechanisms of somatic hypermutation
In collaboration with Dr Jo Spencer
As Co-Investigator/Collaborator:
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A novel approach to assessing vaccine efficacy using analysis of immunoglobulin gene sequence mutation induced by protein and lps components with Dr Jo Spencer et al
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Characteristics of TSH-R stimulating antibodies with Prof Paul Banga et al
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B cell subset characteristics in ageing with Prof Calogera Caruso and Dr Guiseppina Colonna-Romano et al, Palermo, Sicily
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Exploring the impact of vertically acquired HIV infection on the quality of humoral immunity in early adulthood with Dr Helen Baxendale et al, Institute of Child Health
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DNA repair molecules in somatic hypermutation and class switch with Dr Pan Hammastrom, Karolinska, Sweden
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Diversification and Selection of Follicular Lymphoma and Diffuse Large B Cell Lymphoma with Prof Ramit Mehr (Bar-Ilan), Prof Freda Stevenson (Southampton) et al
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Lineage tree analysis of B cell clonal diversification in IBD with Prof Iris Barshack and Prof Ramit Mehr (Bar Ilan)