Professor Christer Hogstrand
Diabetes & Nutritional Sciences Division
School of Medicine
King's College London
3.85 Franklin-Wilkins Building
150 Stamford Street
London SE1 9NH
Tel: 44 (0)20 7848 4436
Fax: 44 (0)20 7848 4500
Professor, King’s College London, 2006 – present
Senior Scientist, Norwegian National Institute of Nutrition and Seafood Research (NIFES), 2006 – present
Reader, King’s College London, 2001 – 2005
Lecturer, King’s College London, 1999 – 2001
Center Investigator, University of Miami, 1993 – present
Associate Professor, University of Kentucky, 1999 - 1999
Assistant Professor, University of Kentucky, 1994 - 1999
The role of trace elements in biology and toxicology
Functional genomics and toxicogenomics
The primary focus of my research program is on the biology and toxicology of minerals. In particular, I am interested in how metals and other minerals are regulated by organisms and how metals, primarily zinc, control biological processes. These studies include identification, function, and regulation of transporters and metal binding proteins as well as their respective genes. In our current research, there is an emphasis on post-genomic approaches to study zinc regulation in the vertebrate model species, zebrafish (Danio rerio).
We also investigate effects environmentally problematic metals and persistant organic pollutants (POPs) on biological processes in mammals. Post-genomic and proteomics technologies are explored as tools for class prediction (diagnosis of effects from specific contaminants) and to mechanistically relate negative effects to affected networks. In recent research with an ecotoxicological angle, we developed a cell culture based method to detect specific effects of different metals in natural waters on rainbow trout (Oncorhynchus mykiss) gill cells.
GENOMICS-BASED ASSESSMENT OF TOXICITY IN MICE TO FOUR CONTAMINANTS (2,3,7,8-TCDD, CB-153, BDE-47 AND HBCD) COMMONLY FOUND IN SEAFOOD CARROLL T.S.1,*, Rasinger J.D.1,*, Reffatto V.1,*, Tassinari R.2, Maranghi F.2, Moracci G.2, Haave M.3, Mantovani A.2, Macrì A.2, Lundebye A.K.3, Hogstrand C.1,3,†(2009)
Craig PM, Hogstrand C, Wood CM, McClelland GB. Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio. Physiol Genomics. 2009 Dec 30;40(1):23-33. Epub 2009 Sep 29. PubMed PMID: 19789285.
Glover CN, Zheng D, Jayashankar S, Sales GD, Hogstrand C, Lundebye AK. Methylmercury speciation influences brain gene expression and behavior in gestationally-exposed mice pups. Toxicol Sci. 2009 Aug;110(2):389-400. Epub 2009 May 22. PubMed PMID: 19465457.
Harper DD, Farag AM, Hogstrand C, Macconnell E. Trout density and health in a stream with variable water temperatures and trace element concentrations: does a cold-water source attract trout to increased metal exposure? Environ Toxicol Chem. 2009 Apr;28(4):800-8. PubMed PMID: 19391677.
Hogstrand C, Kille P, Nicholson RI, Taylor KM. Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends MolMed. 2009 Mar;15(3):101-11. Epub 2009 Feb 24. PubMed PMID: 19246244.
Hogstrand C, Zheng D, Feeney G, Cunningham P, Kille P. Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish. Biochem Soc Trans. 2008 Dec;36(Pt 6):1252-7. PubMed PMID: 19021535.
Publication List (pdf, 47 KB)