Dr John Pickup
Professor of Diabetes and Metabolism
Diabetes Research Group
Diabetes & Nutritional Sciences Division
School of Medicine
King's College London
Hodgkin Building 2.92
Guy's Hospital Campus
London SE1 1UL, UK
E.mail: john.pickup@kcl.ac.uk
Tel: +44 (0) 20 7848 6024
Fax: +44 (0) 20 7188 0146
Biography
John Pickup is Professor of Diabetes and Metabolism at King’s College London. He graduated in medicine and completed his DPhil in biochemical endocrinology at the University of Oxford. After a postgraduate appointment in Endocrinology at the Hammersmith Hospital in London and a fellowship in the Endocrine Unit at the Massachusetts General Hospital, Boston, he moved to Guy’s Hospital Medical School (later King’s College London), becoming successively Senior Lecturer, Reader and Professor.
Research interests
Professor Pickup's clinical and research interests are in diabetes. He has a long-standing interest in the development of novel technology for the improved management of diabetes, starting from the development of continuous subcutaneous insulin infusion, through to in vivo glucose sensors. His current research focuses on the clinical application of insulin pump therapy and continuous and self blood glucose monitoring, fluorescence methods for sensing glucose and applications of nanomedicine in diabetes research. Other research interests include activation of the innate immune system and inflammation as a cause of type 2 diabetes.
He has had a long-term collaboration with the University of Strathclyde investigating applications of photophysics in clinical medicine, and is Visiting Professor in the Dept of Physics. Recent grants include a £4.3 million Science and Innovation award from the EPSRC for nanometrology research, in collaboration with the University of Strathclyde. This involves the setting up of a Nanomedicine Unit at King’s College London which will focus on applications in diabetes and metabolism.
John Pickup is the co-editor of the multi-award-winning ‘Textbook of Diabetes’ and ‘Handbook of Diabetes’ (Blackwell Publishers), now in their third editions, and he is the recipient of several research awards, including the R D Lawrence Lectureship of Diabetes UK, the Gotch Prize of Oxford University, the Boehringer Mannheim Fellowship of the Biochemical Society, the BUPA Foundation Research Award, the Mary Jane Kugel Award of the Juvenile Diabetes Foundation International and the Diabetes Leadership Award of the Diabetes Technology Society. He is an expert adviser on diabetes to the National Institute for Health and Clinical Excellence.
Publications
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Khan F, Saxl TE, Pickup JC (2010) Fluorescence intensity- and lifetime-based glucose sensing using an engineered high-Kd mutant of glucose/galactose-binding protein, Anal Biochem, 1, 399, 39-43.
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Pickup JC, Hammond P (2009) NICE guidance on continous subcutaneous insulin infusion 2008: review of the technology appraisal guidance, Diabetes, 26, 1-4.
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Pickup JC, Zhi ZL, Khan F, Saxl T, Birch DJ (2008) Nanomedicine and its potential in diabetes research and practice, Diabetes Metab Res Rev, 24, 604-10.
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Pickup JC, Sutton AJ (2008) Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion, Diabet Med, 765-74.
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Fernández-Real JM, Pickup JC. (2008) Innate immunity, insulin resistance and type 2 diabetes. Trends Endocr Metab.; 19: 10-16.
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Khan F, Gnudi L, Pickup JC (2008) Fluorescence-based sensing of glucose using engineered glucose/galactose-binding protein: a comparison of fluorescence resonance energy transfer and environmentally sensitive dye labelling strategies. Biochem Biophys Res Commun.;365: 102-106.
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Soedamah-Muthu SS, Chaturvedi N, Pickup JC, Fuller JH; EURODIAB Prospective Complications Study Group (2008) Relationship between plasma sialic acid and fibrinogen concentration and incident micro- and macrovascular complications in type 1 diabetes. The EURODIAB Prospective Complications Study (PCS), Diabetologia, 51, 493-501.
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Pickup JC (2007) Biosensors for monitoring metabolites in clinical medicine. In: Handbook of Biosensors and Biochips, ed Marks RS, Cullen D, Lowe C, Weetall H, Karube I, John Wiley.
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Pickup JC, Harris A (2007) Assessing quality of life for new diabetes treatments and technologies: a simple patient-centered score. J Diabetes Sci Technol; 1: 394-399.
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McGuiness CD, Macmillan AM, Karolin J, Smith WE, Graham D, Pickup JC, Birch DJS (2007) Single molecule level detection of allophycocyanin by surface enhanced resonance Raman scattering. Analyst; 132: 633-644.
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Pickup JC, Kidd J, Burmiston S, Yemane N (2006) Determinants of glycaemic control in type 1 diabetes during intensified therapy with multiple daily insulin injections or continuous subcutaneous insulin infusion: importance of blood glucose variability. Diab Metab Res Rev; 22: 232-7.
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Pickup JC, Kidd J, Burmiston S, Yemane N. (2005) Effectiveness of continuous subcutaneous insulin infusion in hypoglycaemia-prone type 1 diabetes: implications for NICE guidelines. Pract Diab Int; 22: 10-14.
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Hussain F, Birch DJS, Pickup J. (2005) Glucose sensing based on the intrinsic fluorescence of sol-gel immobilized yeast hexokinase. Analyt Biochem; 339: 137-43.
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Evans ND, Gnudi L, Rolinski OJ, Birch DJS, Pickup JC. (2005) Glucose-dependent changes in NAD(P)H-related fluorescence lifetime of adipocytes and fibroblasts in vitro: potential for non-invasive glucose sensing in diabetes mellitus. J Photobiol Photochem B; 80: 122-9.
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Pickup JC. (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care; 27: 813-823.
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Pickup JC. (2004) Glucose sensors: present and future. In: International Textbook of Diabetes, 3rd edn, DeFronzo R, Ferrannini E, Keen H, Zimmet P (eds), pp 1685-94, John Wiley, Chichester.
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Sachedina N, Pickup JC. (2003) Performance assessment of the Medtronic-MiniMed Continuous Glucose Monitoring System and its use for measurement of glycaemic control in type 1 diabetes. Diabet Med; 20: 1012-1015.
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Pickup JC, Williams G (eds). Textbook of Diabetes, 3rd edn. Blackwell Publishing, Oxford, 2003.