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Dr John Pickup

Professor of Diabetes and Metabolism
Diabetes Research Group, 

Diabetes & Nutritional Sciences Division, 
School of Medicine, 
King's College London, 
Hodgkin Building 2.92, 
Guy's Hospital Campus, 
London SE1 1UL, UK, 
E.mail: john.pickup@kcl.ac.uk
Tel: +44 (0) 20 7848 6024

Biography

John Pickup is Professor of Diabetes and Metabolism at King’s College London. He graduated in medicine and completed his DPhil in biochemical endocrinology at the University of Oxford. After a postgraduate appointment in Endocrinology at the Hammersmith Hospital in London and a fellowship in the Endocrine Unit at the Massachusetts General Hospital, Boston, he moved to Guy’s Hospital Medical School (later King’s College London), becoming successively Senior Lecturer, Reader and Professor. He has also been visiting Professor in the Dept of Physics at the University of Strathclyde since 2005. 

Research interests

Professor Pickup's clinical and research interests are in diabetes. He has a long-standing interest in the development of novel technology for the improved management of diabetes, starting from the development of continuous subcutaneous insulin infusion (insulin pump therapy), through to in vivo glucose sensors.  His current research focuses on the clinical application of insulin pump therapy and continuous glucose monitoring in diabetes, fluorescence methods for sensing glucose and applications of nanomedicine in diabetes research – including islet cell nano-encapsulation and glucose nanosensors. Other research interests include activation of the innate immune system and inflammation as a cause of type 2 diabetes and the complications of diabetes such as depression. 

Measures of Esteem

John Pickup has received a number of research awards, including the R D Lawrence Lectureship of Diabetes UK, the Gotch Prize of Oxford University, the Boehringer Mannheim Fellowship of the Biochemical Society, the BUPA Foundation Research Award, the Mary Jane Kugel Award of the Juvenile Diabetes Research Foundation, the Diabetes Leadership Award of the Diabetes Technology Society and the Banting Award of Diabetes UK for 2014. He has also received several book awards for the Textbook of Diabetes and Handbook of Diabetes, including the Charlesworth Award and the BMA Book of the Year, as well as winner of the Society of Authors and Royal Society of Medicine Book Awards.

John Pickup has been an invited lecturer, keynote speaker and/or chairman at many hundreds of national and international meetings of learned societies, including Diabetes UK, EASD, ADA, IDF, JDRF, Keystone Conference, the British Council (Course Chairman on two occasions), the All Party Parliamentary Groups on Diabetes and Medical Technology, NIH, NASA and at diabetes associations and meetings in more than 25 countries. He served as a member of the Diabetes UK Research Committee from 2007-2012, and was Chairman of the EFSD Glucose Monitoring panel for four years. He has been chairman of the JDRF Artifical Pancreas Programme Data Safety and Monitoring Board (DSMB) since 2008 and currently serves as a member of the DSMB or Trial Steering Committee for four other trials. He has been an adviser on diabetes to many agencies including the Scottish Intercollegiate Guidance Network, NHS Clinical Knowledge, NHS Purchasing and Supply Agency, Health Technology Assessment Unit, NHS Technology Adoption Centre, the Work Foundation, the US Federal Bureau of Investigation, Royal Society of Edinburgh, Association of British Pharmaceutical Industries, and the Academy of Finland, as well as to NICE and the NICE Early Advice to Industry scheme.

Key Grants Held

  • EPSRC, In vivo fluorescence lifetime sensing in clinical medicine: research into glucose sensing, £335,000
  • Wellcome Trust  (Sir Henry Wellcome Commemorative Award for Innovative Research), Single and multi-photon excited skin-surface fluorescence for non-invasive metabolic  monitoring in diabetes mellitus, £97,700. 
  • EPSRC, Fluorescence photophysics sensing of glucose in diabetes. £137,000, with D Birch and L Gnudi.
  • Wellcome Trust (Sir Henry Wellcome Commemorative Award for Innovative Research), Structural sensing of metabolites using fluorescence resonance energy transfer, £140,600.
  • EPSRC, Single Molecule Sensing in Clinical Medicine, £527,000 (with D Birch)
  • EPSRC/Higher Education Funding Council (Science and Innovation Award), Nanometrology for Molecular Science, Medicine and Manufacture, £4.3 million (with University of Strathclyde).

Publications

  • Pickup J C. Insulin pump therapy for type 1 diabetes. N Engl J Med 2012; 366-324                
  • Zhi Z-L, Kerby A,  King AJF, Jones PM, Pickup JC. Nanoscale encapsulation enhances allograft survival and function of islets transplanted in diabetic mice. Diabetologia 2012; 55: 1081-90.         
  • Pickup JC, Freeman SC, Sutton AJ. Glycaemic control in type 1 diabetes during real-time continuous glucose monitoring compared to self-monitoring of blood glucose: meta-analysis of randomized controlled trials using individual patient data. BMJ 2011; 343: d3805.          
  • Pickup JC, Sutton AJ. Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion, Diabet Med 2008; 25: 765-74. 
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