Wendy Hall key projects
CRESSIDA (Cardiovascular risk REduction Study: Supported by an Integrated Dietary Approach)
Role: Co-investigator. The project is a randomised controlled trial (RCT) comparing a cardioprotective diet with a traditional UK diet on CVD risk factors and vascular function in non-smoking men and women aged 40-70 y, who because of their age are at increased risk of CVD. The cardioprotective diet will supply <6 g/d and SFA <10 % energy, increased wholegrains >50% cereal intake, 5 portions fruit and vegetables/d and increased fish intake 2 portions/week one of which should be oily. The findings of this study will provide robust dietary advice to help prevent CVD. The research team includes Prof Tom Sanders (principal investigator), Dianne Reidlinger (research die titian), Dr Julia Darzi (postdoctoral researcher), Virginia Govoni (research technician), Laura O’Sullivan (research administrator), Dr Louise Goff (coinvestigator) and Dr Sarah Berry (co-investigator). Funded by the Department of Health. Jan 2010-Dec 2012.
IRIS (Interesterified fatty acids and Remnant lipoprotein Intervention Study)
Role: Chief investigator. The project is a randomised controlled trial (RCT) comparing the effects of two types of palm oil that differ in their physical properties such as melting point on postprandial lipaemia and vascular function in men aged 40-70 y, who have slightly raised fasting plasma triglyceride concentrations. The findings of this study will determine whether commercially available fats commonly used by the food industry in baked goods have any implications for cardiovascular health. The research team includes Dr Sarah Berry, Androulla Filippou (PhD student) and Prof Tom Sanders, April 2011-Aug 2011.
Unravelling the mechanisms of vascular protection by n-3 PUFAs to optimise and support their use as bioactives by the food industry
Role: Chief investigator. This project is a controlled intervention study comparing the effects of different types of fat (n-6 polyunsaturated fatty acids (PUFA), marine n-3 PUFA, algal n-3 PUFA and monounsaturated fatty acids) on postprandial lipaemia and vascular function in men with slightly raised fasting plasma triglyceride concentrations. Chylomicron remnant-rich lipoprotein fractions from postprandial blood samples will be used to treat cultured endothelial cells and monocytes by collaborators at the Royal Veterinary College to determine intracellular mechanisms for vascular changes. The research team includes includes Dr Sarah Berry and Prof Tom Sanders. Funded by the BBSRC DRINC scheme. Jan 2011-Dec 2012.
A prospective cohort study of laparoscopic sleeve gastrectomy for weight loss in obese patients on haemodialysis: proof of concept
Role: Primary academic supervisor. This clinical intervention trial aims to evaluate the efficacy of the sleeve gastrectomy procedure to elicit sufficient weight loss to enable kidney transplantation in obese patients with kidney failure currently undergoing haemodialysis. Helen McLaughlin (Renal Dietitian/PhD student) is the chief investigator, with other members of the research team including Dr Iain Macdougall (Consultant Nephrologist King’s College Hospital), Mr Ameet Patel (Consultant Surgeon King’s College Hospital), Dr Jonathan Hill (Consultant Cardiologist, King’s College Hospital) and Prof Tom Sanders (Academic supervisor). Funded by King’s College Hospital. Sep 2010- Sep 2012.