There are 4 theme strands, as detailed below.
Inflammatory skin disease
The programme is highly synergistic with ongoing activities in the Division of Immunology, Infection and Inflammatory Disease/Division of Genetics and Molecular Medicine. We will functionally characterise major genetic risk regions and identify novel genomic and proteomic markers in inflammatory skin conditions. We will combine genomic investigations with pharmacological studies into the use of targeted immunological therapies with the aim to identify potential biomarkers for treatment response and adverse effects. Finally, we aim to move cutting edge preclinical research into clinical application.
Genetic skin disease
The programme is developing and refining novel genetic tests for individuals with epidermolysis bullosa and related disorders, including prenatal testing (and pre-implantation genetic diagnosis) for families at risk of genetically determined skin disease. It brings new gene, protein and cell therapies to the clinic for patients with genetic skin disorders.
The skin cancer programme is a significant part of a major new cancer strategy initiative at Guy’s and St. Thomas’ Hospital and King’s College London aiming to create a world leading cancer centre based on its strong partnership. With its established national and international translational research profile, skin cancer features as one of the main focus areas inthe new cancer strategy.
Environment and the skin
Environment/skin interactions are of critical importance in the aetiology and in the management of many skin diseases. Work in this area will identify novel molecular markers of sensitisation risk and thereby permit development of strategies and policies to minimise this risk. In photobiology, work will identify and manipulate molecular pathways responsible for UV-light induced skin inflammation and cancer.