Oleg Aslanidi
Lecturer in Biomedical Engineering
Email: oleg.aslanidi@kcl.ac.uk
Qualifications:
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BSc in Applied Mathematics
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PhD in Biophysics
Biography
Dr Oleg Aslanidi was educated in Russia, receiving his PhD degree from the Institute of Theoretical & Experimental Biophysics in 1999. He worked in several research positions in Russia, Denmark and UK, most recently as Research Fellow in Physics at the University of Manchester. In March 2012 he became a Lecturer in Biomedical Engineering at King’s College London. Throughout his career, Dr Aslanidi developed multi-scale biophysically detailed computational models of cell-to-organ physiological systems, with a strong focus on the heart and cardiac arrhythmias. His research is primarily aimed at dissecting the complex biophysical mechanisms underlying cardiac disease, such that the knowledge arising from predictive modelling can be applied to address specific clinical needs.
Research interests
Atrial fibrillation (AF) is an exemplar cardiac arrhythmia that imposes a huge health and economical burden on the society due to its high prevalence. However, complex mechanisms of AF onset and progression are not well understood. Biophysical modelling provides a quantitative framework for integrating multi-scale and multi-modal information, in order to understand arrhythmogenic patterns that emerge from the interactions of multiple pathophysiological factors underlying AF. Such information include ex-vivo anatomical (diffusion MRI, micro-CT) and functional (cell totissue and organ electrophysiology) data, as well as patient-specific recordings (atrial rate and velocity, regions of fibrosis) to individualise the models. The models can be validated against atrial electrical signals from both invasive (catheter mapping) and non-invasive (ECG) clinical sources, and are applied to dissect the spatio-tempotal dynamics underlying AF. Interactions of AF triggers and substrates and their links with the pathophysiological factors (heart failure, remodelling, adrenergic and vagal responses) can be explored in details that cannot be attained in experimental or clinical settings. Predictions from the patient-specific models can be used to design therapeutic strategies (ablation, pharmacological and cardioversion) aimed at counteracting the factors that predispose to AF, and hence to assist in clinical prevention of the disease.
Group Members
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Dr Marta Varela, Research Associate
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Ross Morgan, PhD Student
Research Funding
British Heart Foundation. Evolution of arrhythmogenic substrate for atrial fibrillation: mechanistic insights from an integrative multi-scale model of canine atria. Oleg Aslanidi (PI), Henggui Zhang, Jules Hancox, Mark Boyett. £148,700. Nov-2010 to Dec-2013.
Publications
Articles in Print Journals
[1] Aslanidi OV, Colman MA, Varela M, Zhao J, Smaill BH, Hancox JC, Boyett MR, Zhang H. Heterogeneous and anisotropic integrative model of pulmonary veins: Computational study of arrhythmogenic substrate for atrial fibrillation. Interface Focus (2013), doi: rsfs.2012.0069.
[2] Butters TD, Aslanidi OV, Zhao J, Smaill BH, Zhang H. A novel computational sheep atria model for the study of atrial fibrillation. Interface Focus (2013), doi: rsfs.2012.0067.
[3] Aslanidi O, Nikolaidou T, Zhao J, Smaill BH, Gilbert SH, Holden AV, Jarvis JC, Stephenson RS, Hancox JC, Boyett MR, Zhang H. Application of X-ray micro-computed tomography with iodine staining to cardiac imaging, segmentation and computational model development. IEEE Transactions on Medical Imaging 32 (2013), 8-17
[4] Nikolaidou T, Aslanidi OV, Zhang H, Efimov IR. Structure-function relationship in the sinus and atrioventricular nodes. Pediatric Cardiology 33 (2012), 890-99.
[5] Abd-Allah ESH, Aslanidi OV, Tellez JO, Yanni J, Billeter R, Zhang H, Dobrzynski H, Boyett MR. Postnatal development of transmural gradients in expression of ion channels and Ca2+-handling proteins in the ventricle. Journal of Molecular & Cellular Cardiology 53 (2012), 145-55.
[6] Aslanidi OV, Colman MA, Stott J, Dobrzynski H, Boyett MR, Holden AV, Zhang H. 3D virtual human atria: A computational platform for studying clinical atrial fibrillation. Progress in Biophysics & Molecular Biology 107 (2011), 156-168.
[7] Aslanidi OV, Benson AP, Colman MA, Gilbert SH, Garratt CJ, Greenwood J, Holden AV, Kharche S, Plein S, Stott J, Zhang H. Virtual tissue engineering of the human atria: modelling pharmacological actions on atrial arryhthmogenesis. European Journal of Pharmaceutical Sciences 46 (2012), 209-21.
[8] Colman MA, Aslanidi OV, Stott J, Holden AV, Zhang H. Correlation between P-wave morphology and origin of atrial focal tachycardia – Insights from realistic models of human atria and torso. IEEE Transactions on Biomedical Engineering 58 (2011), 2952-2955.
[9] Aslanidi OV, Atia J, Benson AP, van den Berg HA, Choi C, Gilbert SH, Goryanin I, Holden AV, Li P, Norman JE, Simpson NA, Taggart MJ, Tong WC, Zhang H. Towards a computational reconstruction of the electrodynamics of premature and full term human labour. Progress in Biophysics & Molecular Biology 107 (2011), 183-192.
[10] Chandler NJ, Aslanidi OV, Buckley DL, Inada S, Birchall S, Atkinson AJ, Kirk D, Molenaar P, Anderson RH, Sharma V, Sigg DC, Zhang H, Boyett MR, Dobrzynski H. Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area. The Anatomical Record 294 (2011), 970-979.
[11] Aslanidi OV, Sleiman RN, Boyett MR, Hancox JC, Zhang H. Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells. Biophysical Journal 98 (2010), 2420-2431.
[12] Butters TD, Aslanidi OV, Inada S, Boyett MR, Hancox JC, Lei M, Zhang H. Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circulation Research 107 (2010), 126-137.
[13] Aslanidi OV, Stewart P, Boyett MR, Zhang H. Response: Optimal velocity can arise from various discontinuities. Biophysical Journal 98 (2010), 3104-3105.
[14] Aslanidi OV, Stewart P, Boyett MR, Zhang H. Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction. Biophysical Journal 97 (2009), 20-39.
[15] Stewart P, Aslanidi OV, Noble D, Noble P, Boyett MR, Zhang H. Mathematical models of the action potential of Purkinje cells. Philosophical Transactions of the Royal Society A 367 (2009), 2225-2255.
[16] Aslanidi OV, Benson AP, Boyett MR, Zhang H. Mechanisms of defibrillation by standing waves in the bidomain ventricular tissue with voltage applied in an external bath. Physica D: Nonlinear Phenomena 238 (2009), 984-991.
[17] Aslanidi OV, Boyett MR, Dobrzynski H, Li J, Zhang H. Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy. Biophysical Journal 96 (2009), 798-817.
[18] Aslanidi OV, Boyett MR, Zhang H. Left to right atrial electrophysiological differences: Substrate for a dominant reentrant source during atrial fibrillation. Lecture Notes in Computer Science 5528 (2009), 154-161.
[19] Benson AP, Aslanidi OV, Zhang H, Holden AV. The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Progress in Biophysics & Molecular Biology 96 (2008), 187-208.
[20] Holden AV, Aslanidi OV, Benson AP, Clayton RH, Halley G, Li P, Tong WC. The virtual ventricular wall: A tool for exploring cardiac propagation and arrhythmogenesis. Journal of Biological Physics 32 (2006), 355-368.
[21] Aslanidi OV, Lambert JL, Srinivasan NT, Holden AV. Virtual ventricular wall: effects of pathophysiology and pharmacology on transmural propagation. Lecture Notes in Computer Science 3504 (2005), 162-171.
[22] Aslanidi OV, Clayton RH, Lambert JL, Holden AV. Dynamical and cellular electrophysiological mechanisms of ECG changes during ischaemia. Journal of Theoretical Biology 237 (2005), 369-381.
[23] Aslanidi OV, Clayton RH, Holden AV, Philips H, Ward R. Vulnerability to re-entry, and drift, stability and breakdown of spiral waves in a linear gradient in the Luo-Rudy virtual ventricular tissue. International Journal of Bifurcation & Chaos 13 (2003), 3865-3871.
[24] Aslanidi OV, Holden AV. A simple model for interaction of voltage and calcium dynamics in ventricular tissue. International Journal of Bifurcation & Chaos 13 (2003), 3873-3886.
[25] Mornev OA, Tsyganov IM, Aslanidi OV, Tsyganov MA. Beyond boundaries of the Kuramoto-Zeldovich theory: stably rotating concave spiral waves and their link to the echo phenomenon. Journal of Experimental & Theoretical Physics Letters 77 (2003), 270-275.
[26] Aslanidi OV, Bailey A, Biktashev VN, Clayton RH, Holden AV. Enhanced self-termination of re-entrant arrhythmias as a pharmacological strategy for anti-arrhythmic action. Chaos 12 (2002), 843-851.
[27] Aslanidi OV, Mornev OA, Vesterager M, Soerensen MP, Christiansen PL. A model for glucose-induced wave propagation in pancreatic islets of Langerhans. Journal of Theoretical Biology 215 (2002), 273-286.
[28] Aslanidi OV, Mornev OA, Skyggebjerg O, Arkhammar P, Thastrup O, Soerensen MP, Christiansen PL, Conradsen K, Scott AC. Wave propagation as the possible mechanism for transmission of calcium signals in pancreatic islets of Langerhans. Biophysical Journal 80 (2001), 1195-1209.
[29] Gray RA, Mornev OV, Jalife J, Aslanidi OV, Pertsov AM. Standing excitation waves in the heart induced by strong alternating electric fields. Physical Review Letters 87 (2001), 168104-8108.
[30] Kochetkov KV, Kazachenko VN, Aslanidi OV, Chemeris NK, Gapeyev AB. Non-markovian gating of Ca2+-activated K+ channel in cultured kidney cells. Rescaled range analysis. Journal of Biological Physics 25/2 (1999), 211-222.
[31] Aslanidi OV, Mornev OA. Soliton-like regimes and excitation wave reflection (echo) in homogeneous cardiac Purkinje fibers: results of numerical simulations. Journal of Biological Physics 25/2 (1999), 149-164.
[32] Aslanidi OV, Mornev OA. Can colliding nerve pulses be reflected? Journal of Experimental & Theoretical Physics Letters 65 (1997), 579-584.
Conference Papers in Books (Print)
[33] Aslanidi OV, Colman MA, Zhao J, Smaill BH, Gilbert SH, Hancox JC, Boyett MR, Zhang H. Arrhythmogenic substrate for atrial fibrillation: Insights from an integrative computational model of pulmonary veins. Proceedings of IEEE Engineering in Medicine & Biology Society (2012), 203-206.
[34] Aslanidi OV, Butters TD, Ren CX, Ryecroft G, Zhang H. Electrophysiological models for the heterogeneous canine atria: Computational platform for studying rapid atrial arrhythmias. Proceedings of IEEE Engineering in Medicine & Biology Society (2011), 1693-1696.
[35] Higham J, Aslanidi OV, Holden AV, Zhang H. Large speed increase using novel GPU based algorithms to simulate cardiac excitation waves in rabbit ventricles. Computers in Cardiology 38 (2011), 9-12.
[36] Aslanidi OV, Robinson R, Cheverton D, Boyett MR, Zhang H. Electrophysiological substrate for a dominant reentrant source during atrial fibrillation. Proceedings of IEEE Engineering in Medicine & Biology Society (2009), 2819-2822.
[37] Aslanidi OV, Dewey RS, Morgan AR, Boyett MR, Zhang H. Electrophysiologically detailed models of the right and left rabbit atria: pharmacological impacts on propagation and arrhythmogenesis. Computers in Cardiology 35 (2008), 69-72.
[38] Stewart P, Aslanidi OV, Boyett MR, Zhang H. Optimal safety of conduction through the Purkinje-ventricular junction. Computers in Cardiology 35 (2008), 303-306.
[39] Aslanidi OV, Boyett MR, Zhang H. Effects of intracellular Ca2+ dynamics on restitution properties and stability of reentry in a rabbit atrial tissue model. Computers in Cardiology 35 (2008), 295-297.
[40] Aslanidi OV, Dewey RS, Morgan AR, Boyett MR, Zhang H. Regional differences in rabbit atrial action potential properties: mechanisms and pharmacological implications. Proceedings of IEEE Engineering in Medicine & Biology Society (2008), 141-144.
[41] Aslanidi OV, Sleiman RN, Williamson H, Boyett MR, Zhang H. Modeling conduction through the Purkinje-ventricular junction and the short-QT syndrome associated with HERG mutation in the rabbit ventricles. Computers in Cardiology 34 (2007), 241-244.
[42] Stewart P, Aslanidi OV, Zhang H. A novel mathematical model of the electrical action potential in a canine Purkinje fiber cell. Computers in Cardiology 34 (2007), 363-366.
[43] Aslanidi OV, Boyett MR, Zhang H. Computer reconstruction of the cardiac pacemaker. Computers in Cardiology 33 (2006), 9-12.
[44] Benson AP, Aslanidi OV, Zhang H, Holden AV. A three-dimensional model of canine cardiac ventricular wall electrophysiology. Computers in Cardiology 33 (2006), 789-792.
[45] Aslanidi OV, Biktashev VN, Clayton RH, Holden AV. Towards understanding the physical basis of re-entrant cardiac arrhythmias. Studies in Multidisciplinarity 3 (2005), 389-410.
[46] Aslanidi OV, Brodlie KW, Clayton RH, Handley JW, Holden AV, Wood J. Remote visualization and computational steering of cardiac virtual tissues using gViz. Proceedings of EPSRC UK e-Science All Hands Meeting (2005), 433-437.
[47] Sorensen MP, Petersen MV, Aslanidi OV. Coherent dynamics of excitable and coupled beta-cells. Progress in Industrial Mathematics 5 (2004), 375-379.
[48] Aslanidi OV, Biktashev, VN, Chen, M, Clayton RH, Holden AV, Tucker JV, Zhang H. Computational biology of cardiac arrhythmias: from basic science to clinical application. Proceedings of EPSRC UK e-Science All Hands Meeting (2003), 889-896.
[49] Aslanidi OV, Holden AV, Mornev OV. Low-voltage defibrillation in bidomain virtual ventricular tissue: effect of the bath. Computers in Cardiology 29 (2002), 255-258.
[50] Aslanidi OV, Clayton RH, Holden AV. Re-entry in the Luo-Rudy ventricular tissue with different models of Ca2+ dynamics. Computers in Cardiology 28 (2001), 233-236.
[51] Mornev OA, Aslanidi OV, Tsyganov IM. Soliton-like regimes and concave spiral waves in models of biological excitable media. Macromolecular Symposia 160 (2000), 115-118.
Articles in Print Journals (Russian)
[52] Aslanidi GV, Aslanidi OV, Tsyganov MA, Holden AV, Ivanitsky GR. Conditions causing wavefront instability in a growing colony of bacterial cells with chemotactic activity. Doklady Biochemistry & Biophysics 394 (2004), 18-20.
[53] Kochetkov KV, Kazachenko VN, Aslanidi OV. Employment of the wavelet transformation for analysis of single ion channel activity. Membrane & Cell Biology 20 (2003), 359-368.
[54] Kazachenko VN, Kochetkov KV, Aslanidi OV, Grinevich AA. Study of fractal properties of single ionic channel gating mechanism by the fast Fourier transform. Biofizika 46 (2001), 1062-1070.
[55] Aslanidi KB, Pogorelov AG, Aslanidi OV, Mornev OA. Potassium gradients in the growing hyphae of Neurospora crassa. Membrane & Cell Biology 14 (2001), 487-495.
[56] Aslanidi KB, Pogorelov AG, Aslanidi OV, Mornev OA, Potapova TV. Measurements of potassium distribution in Neurospora crassa hyphae. Doklady Biophysics 372 (2000), 253-56.
[57] Mornev OA, Tsyganov IM, Aslanidi OV, Ordanovich AE, Chailakhyan LM. Soliton-like mode in two-dimensional excitable medium: echo effects induced by collision of excitation waves with local nonconductive medium elements. Doklady Biophysics 373-75 (2000), 32-36.
[58] Aslanidi OV, Mornev OA. "Echo" in excitable cardiac fibres (numerical simulations approach). Mathematical Modelling 11 (1999), 3-22.
[59] Aslanidi KB, Aslanidi OV, Mornev OA. Analysis of electrical phenomena accompanying growth of colonies of cultured mammalian cells. A mathematical model. Membrane & Cell Biology 11 (1998), 771-778.
[60] Mornev OA, Aslanidi OV. New regimes in uniform excitable media with refractoriness: reflection of colliding excitation impulses. Membrane & Cell Biology 11 (1998), 763-768.
[61] Aslanidi KB, Aslanidi OV, Vachadze DM, Mornev OA, Potapova TV. A mathematical model for electric processes during polarized growth of Neurospora Crassa hyphae. Biofizika 42 (1997), 953-965.
[62] Aslanidi KB, Aslanidi OV, Vachadze DM, Potapova TV, Chailakhyan LM. Energetic and metabolic intercellular interactions at the growth region of Neurospora crassa. Doklady Biophysics 352 (1997), 826-830.
[63] Mornev OA, Aslanidi OV, Chailakhyan LM. Soliton-like mode in the FitzHugh-Nagumo equations: dynamics of a rotating spiral wave. Doklady Biophysics 352-54 (1997), 29-32.
[64] Mornev OA, Aslanidi OV, Aliev RR, Chailakhyan LM. Soliton-like regimes in the FitzHugh-Nagumo model: reflection of the colliding pulses of excitation. Doklady Biophysics 346-48 (1996), 21-24.
[65] Aslanidi OV, Mornev OA. Reflection of travelling pulses of excitation. Biofizika 41 (1996), 953-959.
[66] Mornev OA, Aslanidi OV, Chailakhyan LM, Starmer CF. Splitting of the back front of a propagating pulse of excitation. Biofizika 41 (1996), 191-195.
Meeting Abstracts in Journals (Print)
[67] Sleiman RN, Aslanidi OV, Zhang H. Electrophysiological effects of heart failure in the ventricular wall: insights from computational modelling. Acta Physiologica 198 (2010), S109.
[68] Benson AP, Gilbert SH, Aslanidi OV, Zhang H, Boyett MR, Dobrzynski H, Holden AV. 0.2 mm cubic voxel reconstruction of rabbit heart geometry and architecture using diffusion tensor magnetic resonance imaging. Proceedings of Physiological Society 10 (2008), PC11.
[69] Aslanidi OV, Sleiman RN, Higham J, Inada S, Boyett MR, Holden AV, Zhang H. Propagation in an electrophysiologically detailed 1-dimensional model of the whole rabbit heart. Proceedings of Physiological Society 10 (2008), PC27.
[70] Aslanidi OV, Buckley DL, Boeytt MR, Zhang H, Dobrzynski H. Diffusion tensor MRI of the human sinoatrial and atrioventricular nodes. Heart Rhythm 4 (2007), S160.
[71] Stewart P, Aslanidi OV, Boyett MR, Zhang H. Optimal safety of conduction through the Purkinje-ventricular junction. Proceedings of Physiological Society 10 (2008), PC31.
[72] Aslanidi OV, Stewart P, Boyett MR, Zhang H. Modelling conduction through the Purkinje-ventricular junction and the short-QT syndrome associated with HERG mutation in canine ventricles. Proceedings of Physiological Society 8 (2007), PC38.
[73] Aslanidi OV, Sleiman RN, Williamson H, Boyett MR, Zhang H. Electrophysiologically detailed models for transmural heterogeneity and propagation in the rabbit ventricles. Proceedings of Life Sciences (2007), PC349.
[74] Benson AP, Aslanidi OV, Zhang H, Holden AV. A model of canine cardiac ventricular wall electrophysiology. Proceedings of Physiological Society 3 (2006), PC91.
[75] Aslanidi OV, Benson AP, Holden AV, Zhang H. Quantifying the effects of Class III drugs on the canine ventricular tissue. Proceedings of Physiological Society 3 (2006), PC92.
[76] Aslanidi OV, Boyett MR, Zhang H. Reconstructing spatiotemporal electrical activity of the rabbit sinoatrial node. Heart Rhythm 3 (2006), S185.
[77] Aslanidi OV, Hsu EW, Holden AV. Stabilization of re-entry in canine virtual ventricles by decreasing slow inward Ca2+ current. Journal of Physiology 567P (2005), PC10.
[78] Aslanidi OV, Holden AV. Transmural heterogeneity and vulnerability to re-entry in virtual cardiac tissue. FASEB Journal 19 (2005), A1631.
[79] Aslanidi OV, Mornev OA, Pertsov AM, Holden AV. Far-field effect in bidomain model with a bath is defined by multiple space constants. Journal of Physiology 557P (2004), PC9.
[80] Aslanidi OV, Srinivasan NT, Holden AV. Effects of Class III antiarrhythmic drugs on vulnerable properties of virtual ventricular tissue. Journal of Physiology 561P (2004), PC23.
[81] Aslanidi OV, Gray RA, Holden AV, Mornev OA. Standing waves in tridomain virtual ventricular tissue. European Journal of Physiology 443 (2002), S259.
[82] Aslanidi OV, Mornev OA, Holden, AV. Bidomain virtual ventricular tissue: role of the external bath in defibrillation. Journal of Physiology 544 (2002), 4P.
[83] Aslanidi OV, Biktashev VN, Clayton RH, Holden AV. Differential meander of re-entrant spiral waves in mammalian virtual ventricular tissue. Journal of Physiology 536P (2001), 133.
[84] Aslanidi OV. Interaction of multiple pathways for intracellular signalling in the system of insulin-secreting beta-cells. Biophysical Journal 80 (2001), 2763.