Immunoregulation & Immune Intervention
Professor Giovanna Lombardi
Professor Randolph Noelle
The Immunoregulation and Immune Intervention section is led by Professors Giovanna Lombardi and Randolph Noelle and is based at the Guy's Campus of KCL. The Section, which includes Professor Robert Lechler, Dr Stipo Jurcevic and Dr Wilson Wong, covers a wide range of research including the following major themes:
The study of the mechanisms that lead to the induction of tolerance in the context of transplantation to then translate findings for immunotherapy.
Transplantation tolerance; the central aim of this research is to persuade the immune system to “tolerate” the foreign organ while retaining full capability to fight off infections and cancer.
A focus on five areas of immunobiology that are relevant to CD40 function; Regulatory T cell biology, B cell memory and plasma cell development, Immune tolerance in transplantation, Cancer vaccines, Translational Immunotherapy.
The development of clinically applicable therapies in transplantation and immunological diseases including the selective targeting of activated T cells
The study of transplantation immunobiology using experimental in vivo models of organ transplantation as well as in the clinical setting.