Dr Yacoub Khalaf
MBBCH (Hons.) MSc (Hons.) MD, FRCOG, MFFP
The Assisted Conception Unit
11th Floor, Tower Wing
Guy's Hospital
London SE1 9RT
Tel:02071888042
Fax:02071880490
Email: Yakoub.khalaf@kcl.ac.uk
Biography
He qualified in Egypt 1984 (Assiut University) with Honours and completed his MD in Birmingham (UK) in 1994. Following research posts in Birmingham and London, he became a Lecturer in the Department of Obstetrics and Gynaecology in 1996, Subspecialty Fellow in Reproductive Medicine and Surgery in 1998 and was appointed Consultant in Gynaecology and Reproductive Medicine in 2001 at Guy’s and St Thomas’ Hospital NHS Foundation Trust (GSTT).
In 2003 he was appointed as an Honorary Senior Lecturer in Reproductive Medicine and Surgery at King’s College London.
In 2004, he was appointed as a Medical Director and HFEA Person Responsible for the Assisted Conception Unit (ACU) at GSTT a post that he holds to date.
Over the past 15 years, he has been making a significant contribution to the development of the ACU to its current status as a leading centre for Assisted Reproduction, Pre-implantation Genetic Diagnosis (PGD) and Stem Cell research.
PI for HTA funded RCT and CI for a national RCT.
Supervisor of numerous BSc, SMM and 2 PhD students
He is an advisor to the Human Fertilisation and Embryology Authority (HFEA), a member of HFEA Licensed Centres. He is a co-opted member of the Training Subcommittee of the British Fertility Society. And an executive board member of the National Clinical Study Group in Reproductive Medicine. He has published and lectured widely on all aspects of assisted conception, in particular, fibroids and IVF and PGD.
Research interests
Infertility, Uterine Fibroids, Assisted Conception, PGD. Recurrent Miscarriage, Stem cell.
PhD students/staff/ groups associated with
2 PhD students, Research Nurse
Reproductive Medicine
Recent Publications
2012
Pundir J, Sunkara SK, El-Toukhy T, Khalaf Y. Meta-analysis of GnRH antagonist protocols: do they reduce the risk of OHSS in PCOS? Reprod Biomed Online 2012;24: 6-22.
2011
Al Ali A, Al Shawaf H, Al Khalaf Y. Stroke caused by left ventricular myxoma. J Am Coll Cardiol 2011;57: e11.
Bint SM, Ogilvie CM, Flinter FA, Khalaf Y, Scriven PN. Meiotic segregation of Robertsonian translocations ascertained in cleavage-stage embryos--implications for preimplantation genetic diagnosis. Hum Reprod 2011;26: 1575-84.
El-Toukhy T, Wharf E, Walavalkar R, Singh A, Bolton V, Khalaf Y, Braude P. Delayed blastocyst development does not influence the outcome of frozen-thawed transfer cycles. BJOG 2011;118: 1551-6.
Hamoda H, Pepas L, Freed C, Grace J, Khalaf Y, Braude P, El-Toukhy T. Outcomes of ovarian stimulation in a two-day oocyte collection week with PGD cycles compared to a five-day oocyte collection week with conventional IVF/ICSI cycles. Hum Fertil (Camb) 2011;14: 254-60.
Khalaf Y, Bewley S, Braude P. Reducing multiple pregnancies after assisted reproduction treatment: Quebec says 'Yes, we can!'. Reprod Biomed Online 2011;23: 407-10.
Khalaf Y, El-Toukhy T. The search for a practice model to reduce miscarriage after assisted reproduction. Reprod Biomed Online 2011;23: 695-6.
Pepas L, Macmahon E, El Toukhy T, Khalaf Y, Braude P. Viral screening before each cycle of assisted conception treatment is expensive and unnecessary: a survey of results from a UK inner city clinic. Hum Fertil (Camb) 2011;14: 224-9.
Rittenberg V, Sobaleva S, Ahmad A, Oteng-Ntim E, Bolton V, Khalaf Y, Braude P, El-Toukhy T. Influence of BMI on risk of miscarriage after single blastocyst transfer. Hum Reprod 2011;26: 2642-50.
Sunkara SK, Pundir J, Khalaf Y. Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis. Reprod Biomed Online 2011;22: 545-55.
Bint SM, Mackie Ogilvie C, Flinter FA, Khalaf Y, Scriven PN. Meiotic segregation of Robertsonian translocations ascertained in cleavage-stage embryos--implications for preimplantation genetic diagnosis. Hum Reprod. 2011 Jun;26(6):1575-84.
Sunkara SK, Pundir J, Khalaf Y. Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis. Reprod Biomed Online. 2011 Jun;22(6):545-55.
2010
Ross C; Morriss A; Khairy M; Khalaf Y; Braude P; Coomarasamy A; El-Toukhy T; A systematic review of the effect of oral antioxidants on male infertility. RBM online 2010;20(6):711-23
El-Toukhy Tarek; Khalaf Yacoub A new study of acupuncture in IVF: pointing in the right direction. RBM online 2010;21(3):278-9
Sesh Kamal Sunkara, Athanasios Siozos, Virginia Noelle Bolton, Yakoub Khalaf, Peter Riven Braude, and Tarek El-Toukhy The influence of delayed blastocyst formation on the outcome of frozen-thawed blastocyst transfer: a systematic review and meta-analysis Hum Reprod. 2010;25(8):1906-15.
Bewley S, Moth P, Khalaf Y.A complicated IVF twin pregnancy. Hum. Reprod. 2010 Apr;25(4):1082-4.
2009
El-Toukhy T, Campo R, Sunkara SK, Khalaf Y, Coomarasamy A. A multi-centre randomised controlled study of pre-IVF outpatient hysteroscopy in women with recurrent IVF implantation failure: Trial of Outpatient Hysteroscopy - [TROPHY] in IVF. Reprod Health. 2009 Dec 3;6:20.
Sunkara SK, Khairy M, El-Toukhy T, Khalaf Y, Coomarasamy A. The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum. Reprod. 2010 Feb;25(2):418-29.
El-Toukhy T, Kamal A, Wharf E, Grace J, Bolton V, Khalaf Y, Braude P. Reduction of the multiple pregnancy rate in a preimplantation genetic diagnosis programme after introduction of single blastocyst transfer and cryopreservation of blastocysts biopsied on day 3.Hum Reprod. 2009 Oct;24(10):2642-8.
Ogilvie CM, Renwick PJ, Khalaf Y, Braude PR. First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole. RBM Online. 2009 Aug;19(2):224-7.
Hossam I. Abdalla, Siladitya Bhattacharya, and Yacoub Khalaf. Is meaningful reporting of national IVF outcome data possible? Hum. Reprod. 2010 25(1):9-13.
El-Shawarby and Yakoub Khalaf. Age-specific serum FSH concentrations and their correlation with the outcome of ovarian stimulation for IVF. RBM Online 2009 Vol. 18 No.6. 750–755