Research into Improvement of Outcome of Fertility Treatment
Current research projects primarily involve clinic-based research and systematic reviews which include:
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Association between presences of uterine fibroids and outcome of assisted conception (prospective studies and systematic review) and effect of removal of fibroids prior to IVF on treatment outcome (RCT)
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Antibiotics prophylaxis prior to embryo transfer and its effect on IVF treatment outcome (RCT)
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Study of the effect of demographic characteristics on the reported outcome of IVF treatment (prospective cohort study)
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Factors that affect the outcome of frozen-thawed embryo transfer (RCT/prospective studies)
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Utilisation of extended embryo culture to reduce multiple birth (Prospective study)
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Study of the value of out-patient hysteroscopy in management of unexplained recurrent IVF failure (systematic review and RCT)
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Study of progesterone supplementation for management of unexplained recurrent pregnancy loss (‘PROMISE’, RCT, MRC funded)
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Study of the factors that influence the risk of miscarriage following elective single blastocyst transfer (prospective study)
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Study of the different ovarian stimulation regimes for poor responders (‘PRINT’,systematic review and RCT)
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Study of luteal phase support using subcutaneous progesterone (RCT)
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Study of the effect of acupuncture on the outcome of IVF treatment (systematic review)
The research programme has contributed to some widely cited publications and has influenced clinical practice. Many intercalated Physiology BSc projects and SSM projects have been conducted under supervision by members of the team related to the above research.
Recent publications
Abdalla HI, Bhattacharya S, Khalaf Y (2010) Is meaningful reporting of national IVF outcome data possible? Hum Reprod. 25(1):9-13.
[PubMed]
Bewley S, Moth P, Khalaf Y (2010) A complicated IVF twin pregnancy. Hum Reprod. 25(4):1082-4.
[PubMed]
Ross C, Morriss A, Khairy M, Khalaf Y, Braude P, Coomarasamy A, El-Toukhy T (2010) A systematic review of the effect of oral
antioxidants on male infertility. Reprod Biomed Online 20(6):711-23.
[PubMed]
Sunkara SK, Khairy M, El-Toukhy T, Khalaf Y, Coomarasamy A (2010) The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum Reprod. 25(2):418-29.
[PubMed]
Sunkara SK, Siozos A, Bolton VN, Khalaf Y, Braude PR, El-Toukhy T (2010) The influence of delayed blastocyst formation on the outcome of frozen-thawed blastocyst transfer: a systematic review and meta-analysis. Hum Reprod. 25(8):1906-15.
[PubMed]