Premature birth alters brain connections
Posted on 04/05/2015
Premature birth can alter the connectivity between key areas of the brain, according to a new study led by King’s College London. The findings should help researchers to better understand why premature birth is linked to a greater risk of neurodevelopmental problems, including autistic spectrum disorders and attention deficit disorders.
The NIHR-funded study, published in the journal PNAS, used functional magnetic resonance imaging (fMRI) to look at specific connections in the brains of 66 infants, 47 of whom were born before 33 weeks and were therefore at high risk of neurological impairment, and 19 born at term. The brain connections investigated were between the thalamus and the cortex, connections which develop rapidly during the period a preterm infant is cared for on a neonatal unit.
Researchers found that those born in the normal window of birth (37-42 weeks) showed a remarkably similar structure to adults in these brain regions, strengthening existing evidence that the brain’s network of connections is quite mature at the time of birth.
However, infants born prematurely (before 33 weeks gestation) were found to have less connectivity between areas of the thalamus and particular areas of the brain’s cortex known to support higher cognitive functions, but greater connectivity between the thalamus and an area of primary sensory cortex which is involved in processing signals from the face, lips, jaw, tongue, and throat.
The greater the extent of prematurity, the more marked were the differences in the pattern of brain connectivity.
The authors suggest that the stronger connections involving face and lips in babies born preterm may reflect their early exposure to breastfeeding and bottlefeeding, while the reduced connectivity in other brain regions may be linked to the higher incidence of difficulties seen in later childhood.
Dr Hilary Toulmin, first author from the Centre for the Developing Brain at King’s College London, said: ‘The next stage of our work will be to understand how these findings relate to the learning, concentration and social difficulties which many of these children experience as they grow older.’
Professor David Edwards, senior author from the Centre for the Developing Brain at King’s College London, said: ‘The ability of modern science to image the connections in the brain would have been inconceivable just a few years ago, but we are now able to observe brain development in babies as they grow, and this is likely to produce remarkable benefits for medicine.’
Notes to editors
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‘Specialization and integration of functional thalamocortical connectivity in the human infant’ by Toulmin et al is published in the journal PNAS (Proceedings of the National Academy of Sciences of the USA) on Monday 4 May 2015.
This paper summaries independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant Reference Number RP-PG-0707-10154) and the Medical Research Council (MRC) Strategic Grant ‘Pre-term Brain Injury’.
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The National Institute for Health Research (NIHR) is funded by the Department of Health to improve the health and wealth of the nation through research. Since its establishment in April 2006, the NIHR has transformed research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy, and developed and supported the people who conduct and contribute to applied health research. The NIHR plays a key role in the Government’s strategy for economic growth, attracting investment by the life-sciences industries through its world-class infrastructure for health research. Together, the NIHR people, programmes, centres of excellence and systems represent the most integrated health research system in the world. For further information, visit the NIHR website (www.nihr.ac.uk).