Dr Driton Vllasaliu Academics Supervisors Reader in Biotherapeutics Delivery Research subject areas Pharmacy Contact details driton.vllasaliu@kcl.ac.uk
Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles Self‐Assembled Polypseudorotaxanes Crosslinked by Dynamic Disulfide Bonds as Modular Functionalization for Thiophilic Metal Nanoparticles PEG-PLGA nanoparticles transport across in vitro intestinal epithelial models and show potential for oral delivery of antibodies in inflammatory bowel disease Grand challenges in oral drug delivery Comparison of macromolecule permeation through extracellular matrix and hyaluronic acid to inform in vitro testing of subcutaneous therapies Controlling in vitro lipid digestion: Pickering emulsions with cellulose nanocrystals, chitosan and methylcellulose Mechanistic insight into human milk extracellular vesicle‐intestinal barrier interactions Development of in vitro biopharmaceutics tools for predicting the bioavailability of subcutaneously injected monoclonal antibodies and oligonucleotides Difference in Endocytosis Pathways Used by Differentiated Versus Nondifferentiated Epithelial Caco-2 Cells to Internalize Nanosized Particles In Situ Self-Assembling Liver Spheroids with Synthetic Nanoscaffolds for Preclinical Drug Screening Applications Development of an in vitro co-culture model using Caco-2 and J774A.1 cells to mimic intestinal inflammation Hybrid Milk Extracellular Vesicles as Potential Systems for Oral Delivery of siRNA Polymersomes for protein drug delivery across intestinal mucosa Probing milk extracellular vesicles for intestinal delivery of RNA therapies Enhanced permeation by amphiphilic surfactant is spatially heterogenous at membrane and cell level Exosome-based therapies for mucosal delivery Non-invasive drug delivery systems An Organoid-derived Cell Layer as an in vitro Model for US-mediated Drug Delivery Studies Pulmonary Delivery of Biological Drugs Temperature responsive methylcellulose-hyaluronic hydrogel as a 3D cell culture matrix Exploiting disease-induced changes for targeted oral delivery of biologics and nanomedicines in inflammatory bowel disease Use of Engineered Nanoparticles (ENPs) for the Study of High-Affinity IgE FcεRI Receptor Engagement and Rat Basophilic Leukemia (RBL) Cell Degranulation: Basophils and Mast Cells Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery Recent advances in the oral delivery of biologics Nanoparticle modification in biological media: implications for oral nanomedicines PEGylation affects the self-assembling behaviour of amphiphilic octapeptides PEGylation affects the self-assembling behavior of amphiphilic octapeptides Delivery of nanoparticles across the intestinal epithelium via the transferrin transport pathway Quaternary Ammonium Leucine-Based Surfactants: The Effect of a Benzyl Group on Physicochemical Properties and Antimicrobial Activity Engineering Biomimetic Gelatin Based Nanostructures as Synthetic Substrates for Cell Culture Quaternary ammonium surfactants derived from leucine and methionine: novel challenging surface active molecules with antimicrobial activity Electrospun Nanometer to Micrometer Scale Biomimetic Synthetic Membrane Scaffolds in Drug Delivery and Tissue Engineering: A Review Nanoscale Biomimetic Synthetic Membrane Scaffolds in Drug Delivery and Tissue Engineering: A Review Evaluation of a Methylcellulose and Hyaluronic Acid Hydrogel as a Vehicle for Rectal Delivery of Biologics Ultrasound and Microbubbles Promote the Retention of Fluorescent Compounds in the Small Intestine The Role of Basement Membrane in Intestinal Barrier to Absorption of Macromolecules and Nanoparticles Ascorbyl Palmitate Hydrogel for Local, Intestinal Delivery of Macromolecules Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery Intestinal uptake and transport of albumin nanoparticles: potential for oral delivery Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA Chitosan nanoparticle antigen uptake in epithelial monolayers can predict mucosal but not systemic in vivo immune response by oral delivery Lactose oleate as new biocompatible surfactant for pharmaceutical applications Rhamnolipids as epithelial permeability enhancers for macromolecular therapeutics Neurotensin receptor 1 facilitates intracellular and transepithelial delivery of macromolecules Folic acid conjugated chitosan nanoparticles for tumor targeting of therapeutic and imaging agents. Effect of PEGylation on the toxicity and permeability enhancement of chitosan Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: A comparison PEGylated chitosan derivatives: Synthesis, characterizations and pharmaceutical applications View all publications
24 April 2024 Cows' milk particles used for effective oral delivery of drugs New research has found that tiny particles present in cows’ milk could offer, for the first time, an…