Translational Medicine MSc/PG Dip/PG Cert
Professor Ferro’s research has focused primarily on understanding vascular endothelial and platelet function, with particular reference to the L-arginine / nitric oxide system. His group has been examining signal-transduction mechanisms relating to nitric oxide biosynthesis in endothelial cells and platelets, both in health and in patients with cardiovascular disease states. Current disease areas being investigated are hypertension, diabetes mellitus, ischaemic heart disease and heart failure. A major focus of current research is the understanding of the role of circulating monocyte-platelet aggregates in the pathophysiology of atherosclerosis. The goal of this research programme is to identify novel therapeutic targets for treatment of patients both with established cardiovascular disease and with cardiovascular risk factors. The work involves the complementary use of a variety of techniques such as cell culture, platelet aggregometry, flow cytometry, protein immunodetection, proteomics as well as biochemical assays of biosynthesis both of nitric oxide and of reactive oxygen species. This in vitro work is complemented by in vivo measurements of endothelial and vascular function (in collaboration with Professor Phil Chowienczyk).
International collaborators include Professor Xu Biao (Nanjing University Medical School, China) and Professor Ji Yong (Nanjing Medical University, China).
For further information please see http://www.kcl.ac.uk/schools/medicine/research/cardio/pi/ferro-a.html.