Cariology and Operative Dentistry

The work pursued under this topic includes the following project areas:

• Microbiology of dental caries and endodontic disease – using latest molecular biology techniques to understand complex species diversity, colonisation and the ecological interfaces between the flora and carious dentine/pulp.
• Development of in-vitro, multi-species biofilm models to study caries and endodontic disease and evaluate novel treatments. The use of novel radiographic techniques (Cone Beam Computed Tomography) for the diagnosis of endodontic disease.
• Development of novel diagnostic indicators to aid detection and clinical minimally invasive caries removal using an array of in-vitro and in-vivo microscopy and imaging techniques including confocal fibre-optic micro-endoscopy, electron microscopy, micro-Raman spectroscopy and fluorescence lifetime imaging.
• Investigation of the efficacy and efficiency of novel minimally invasive caries excavation technologies (including pioneering bio-active glass air-abrasion).
• Development of novel adhesive material technologies to "seal and heal" residual caries-affected dentine and endodontically treated teeth (with dental industry collaborations).
• Clinical trials to develop novel caries management strategies for high caries risk individuals (oral oncology and dry mouth patients).