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St John’s Institute of Dermatology is an internationally recognised centre of excellence for the treatment, research and teaching of diseases of the skin. These extend from cancer, through skin inflammation to rare genetic disorders and effects of the environment on the skin. Integrated transitional research programmes exist in each of these sub-specialty areas and are headed by internationally recognised clinicians and scientists. Research spans genetic discovery, through study of disease mechanisms, to clinical research investigating intervention and outcome measures. Research is supported by grants from a range of sources including MRC, Wellcome Trust, EU, British Skin Foundation and commercial sources.
Dermatology
DESCRIPTION
St John’s Hospital for Diseases of the Skin was founded in London in 1868, supported by voluntary contributions. St John’s relocated to St Thomas’ Hospital in the mid 1980s. Soon after, St John’s was formally renamed ‘St John’s Institute of Dermatology’ to include both the St John’s Hospital and the Institute. The academic laboratories of St John’s Institute of Dermatology moved into state-of-the-art new facilities at Guy’s Hospital in April 2007, and is fully integrated into the Division of Genetics and Molecular Medicine, part of the School of Medicine.St John’s Institute of Dermatology is an internationally recognised centre of excellence for the treatment, research and teaching of diseases of the skin. These extend from cancer, through skin inflammation to rare genetic disorders and effects of the environment on the skin. Integrated transitional research programmes exist in each of these sub-specialty areas and are headed by internationally recognised clinicians and scientists. Research spans genetic discovery, through study of disease mechanisms, to clinical research investigating intervention and outcome measures. Research is supported by grants from a range of sources including MRC, Wellcome Trust, EU, British Skin Foundation and commercial sources.
Associated research programmes
Associated staff research interests
Interests:
My research interests include the effects of UVR on immune function, DNA photodamage and its repair, risk factors for skin cancer, UVR-induced oxidative damage and the role of antioxidants, photosensitization (with Dr Robert Sarkany and Dr Susan Walker), endogenous and exogenous photoprotection and how the skin adapts to repeated low dose UVR exposure. I have a long-standing interest in action spectroscopy (wavelength dependence of photobiology effects) and the public health implications.
Tel:
020 7188 6367
Fax:
020 7188 8050
Email:
Website:
Interests:
My main research interest is therapeutics, especially in relationship to inflammatory skin disease, and includes drug development (phase II-IV clinical trials), pharmacogenetics and drug toxicity (severe adverse drug reactions). Clinical research is conducted through the Skin Therapy Research Unit.
Tel:
020 7188 6410
Fax:
020 7188 8050
Email:
Website:
Interests:
Psoriasis: analysis of molecular and immunological pathways of chronic inflammation; studies dissecting the molecular pathways of chronic inflammation in psoriasis using tissue samples' in vitro studies, and state-of-the-art in vivo models; genomic analysis of psoriasis tissue; investigation of the functional role of dendritic cells, conventional T cells and unconventional T cells in psoriasis; development of novel drug targets and testing in the clinic. Melanoma: analysis of molecular and immunological pathways in melanoma - studies on immune activation and immune escape in melanoma patients; dendritic cell targeting of tumour antigens; molecular analysis of melanoma tissues and cell lines; novel approaches to immunotherapy and molecular therapy of melanoma, including definition of biomarkers and mechanism-of-action studies.
http://www.kcl.ac.uk/schools/medicine/depts/dermatology/research/nestle/
http://www.kcl.ac.uk/schools/medicine/depts/dermatology/research/nestle/
Tel:
020 7188 8086
Fax:
020 7188 8050
Email:
Website:
Interests:
Molecular basis of inherited skin disorders: discovering genes for specific diseases, understanding disease mechanisms and determining relevance to diseased and healthy skin; translational research therapies - developing new gene, protein, cell and drug therapies for patients with inherited skin diseases such as epidermolysis bullosa (inherited skin fragility); prenatal diagnosis - development of preimplantation genetic haplotyping for severe inherited skin diseases
Tel:
020 7188 6409
Fax:
020 7188 8050
Email:
Website:
Interests:
My main research interests concern inflammatory skin diseases, such as atopic dermatitis and acne vulgaris, but primarily relate to psoriasis. In this disease, my interests extend from genetic discovery, through pharmacogenetics and disease mechanisms, such as immunology, to clinical research.
Tel:
020 7188 6412
Fax:
020 7188 8050
Email:
Website:
Interests:
Cutaneous T cell lymphoma; molecular characterisation of skin infiltrates; tumour specific antigens; immunisation.
Tel:
020 7188 6410
Fax:
020 7188 8050
Email:
Website:
Fax:
020 7188 8050
Email:
Website:
CONTACTS FOR FURTHER INFORMATION
Professor Jonathan Barker
Email
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