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Immunoregulation & Immune Intervention
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DESCRIPTION
The Immunoregulation and Immune Intervention section is led by Professors Giovanna Lombardi and Randolph Noelle and is based at the Guy's Campus of KCL. The Section which includes Professor Robert Lechler, Dr Stipo Jurcevic and Dr Wilson Wong covers a wide range of research including the following major themes:
- The study of the mechanisms that lead to the induction of tolerance in the context of transplantation to then translate findings for immunotherapy.
- Transplantation tolerance; the central aim of this research is to persuade the immune system to "tolerate" the foreign organ while retaining full capability to fight off infections and cancer.
- A focus on five areas of immunobiology that are relevant to CD40 function; Regulatory T cell biology, B cell memory and plasma cell development, Immune tolerance in transplantation, Cancer vaccines, Translational Immunotherapy.
- The development of clinically applicable therapies in transplantation and immunological diseases including the selective targeting of activated T cells.
- The study of transplantation immunobiology using experimental in vivo models of organ transplantation as well as in the clinical setting.
Associated research programmes
Associated staff research interests
Interests:
Dendritic cell biology; IFN-alpha biology; transplantation tolerance; regulatory T cells.
Tel:
020 7188 7674
Fax:
020 7188 5660
Email:
Website:
Interests:
In 1991, my laboratory identified a novel membrane protein expressed on helper T lymphocytes (Th), CD154. The receptor for CD154 is CD40. This ligand-receptor pair plays a central role in the control of antibody- and cell-mediated immunity and tolerance. Since that time, we have been interested in immune mechanisms of immunity and tolerance that are regulated by CD154. Tolerance induced in the absence of CD154 function is due to the induction of a complex network of regulatory T cells and other hematopoietic cells. We are actively involved in understanding the molecules and cells that are critical for sustaining immune privilege in both allograft tolerance and within the microenvironment of tumors. Novel cells (e.g.mast cells) factors (retinoic acid, new PD-Ls) and networks (Treg-IL-9) are currently being investigated in transplant and tumor models.
In addition to our interests in tolerance, we are actively engaged in the development of CD40-based cancer vaccines for therapeutic intervention in human disease. Finally, as CD40 is a critical player in the regulation of humoral immune memory, the mediators that govern the long-term persistence of humoral immune memory is a significant interest in the laboratory.
In addition to our interests in tolerance, we are actively engaged in the development of CD40-based cancer vaccines for therapeutic intervention in human disease. Finally, as CD40 is a critical player in the regulation of humoral immune memory, the mediators that govern the long-term persistence of humoral immune memory is a significant interest in the laboratory.
Tel:
020 7188 3838
Fax:
020 7188 5660
Email:
Website:
Interests:
Dendritic cell biology; IFN-alpha biology; transplantation tolerance; regulatory T cells.
Tel:
020 7188 8794
Fax:
0207 188 9330
Email:
Website:
Interests:
Activated T cells as a target of immune intervention/development of biomarkers to monitor effects of therapeutic reagents on immune system.
Tel:
020 7188 8193
Fax:
020 7188 5660
Email:
Website:
Interests:
My group has focused on the study of transplantation immunobiology using experimental in vivo models of organ transplantation as well as in the clinical setting. Areas of interest include:
- Natural Killer cells in transplantation
- T cell homeostatic proliferation
- Chronic allograft nephropathy
- Immunological memory in organ transplantation
- Interaction between complement and the adaptive immune response
- Regulatory T cells in transplantation
- Inter-cellular MHC transfer
Tel:
020 7188 1522
Fax:
02071885660
Email:
Website:
CONTACTS FOR FURTHER INFORMATION
Dr Jill Holliday
Email
Website