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Periodontology
DESCRIPTION
The work performed in this topic covers a wide range of research from basic cell biology and immunology to the development and evaluation of novel treatments for periodontal disease.
- Diagnostic and Prognostic Factors in Periodontology
- Salivary and GCF biomarker discovery through proteomic, genetic and other analytical technologies;
- Prognostic factors associated with periodontal treatment outcomes;
- Behavioural and psychosocial factors in periodontal disease.
- Periodontal Disease and Systemic Inflammation
- Regulation of systemic inflammatory markers in disease and during treatment responses;
- Disease association studies.
- Biology of Tissue Regeneration
- Cell biology of bone and periodontal regeneration;
- Role of growth factors and other biological response molecules in bone regeneration;
- Tissue engineering and dental stem cells in tissue regeneration.
- Host-Microbial interactions
- The role of the oral microbiota in periodontal diseases;
- Innate and acquired immune responses and disease.
- Clinical Trials in Periodontology -
- The Department has extensive experience, infrastructure and wide patient base in conducting clinical trials including RCTS both in house and with external sponsors.
Associated research programmes
Associated staff research interests
Interests:
The biology of periodontal regeneration, including understanding the linage and differentiation of cells of the periodontium, the factors that may positively and negatively regulate bone formation and translating tissue engineering principles including periodontal stem cells, bioactive regulators and scaffold materials for novel periodontal therapies;
Risk and prognostic factors and biomarkers for periodontal disease. We are interested in the wide range of environmental, genetic and humoral risk and prognostic factors that may interact to determine susceptibility to periodontitis and how these factors may act. We have become particularly interested in applying proteomic technologies to identify and test for salivary diagnostics which may be useful in the clinic, and ultimately aspire to applying this knowledge for the development of new periodontal treatments.
Risk and prognostic factors and biomarkers for periodontal disease. We are interested in the wide range of environmental, genetic and humoral risk and prognostic factors that may interact to determine susceptibility to periodontitis and how these factors may act. We have become particularly interested in applying proteomic technologies to identify and test for salivary diagnostics which may be useful in the clinic, and ultimately aspire to applying this knowledge for the development of new periodontal treatments.
Tel:
+44 (0)20 7188 4945
Fax:
+44(0) 20 7188 4188
Email:
Website:
Interests:
Restorative Dentistry
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Interests:
Effects of periodontitis on systemic health and inflammation; genetics of periodontitis; peri-implant disease; dentine sensitivity.
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Interests:
Bioactive agents and tissue repair, therapeutic markers in periodontal and allied diseases. This area of investigation is relevant to the management of chronic inflammatory periodontal disease complicated by uncontrolled systemic diseases such as Diabetes mellitus and arthritis. a. Investigation of markers of wound healing in an osteblastic cell culture model simulating an environment of oxidative stress, in order to identify therapeutic strategies. An oxidative environment is induced by using a range of oxidative agents such as glucose oxidised low density lipoprotein, advanced glycaemic end products, C-reactive protein, tumour necrosis factor alpha, interleukin 6 and bacterial lipopolysaccharide. The effects of antioxidants such as glutathione, pycnogenol, co-enzyme Q10, phytoestrogens and minocycline in overcoming oxidative stress are evaluated in this cell culture model. Extrapolation of these findings to the 'in vivo' environment has implications on therapeutic strategies for the periodontal patient. b. Application of osteoconductive and osteogenic bioactive agents in bone defects of periodontal patients and adjunctive anti-oxidant therapy to enhance healing responses.
Tel:
020 7346 3057
Email:
Website:
Interests:
Periodontal disease and osseointegrated dental implants.
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Interests:
Laboratory and clinical research study methods, statistical analysis.
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Interests:
Microbiology and immunology in periodontal disease.
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CONTACTS FOR FURTHER INFORMATION
Professor Francis Hughes
Email
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