Dr Malcolm Lidierth

Senior Lecturer in Physiology

Email: malcolm.lidierth@kcl.ac.uk

Research projects in this laboratory investigate the integration of sensory and motor systems, with particular reference to pain.

Recent Publications

Lidierth, M. sigTOOL: a MATLAB-based environment for sharing laboratory-developed software to analyze biological signals. (2009)
J. Neurosci. Meth. 178, 188-196

Cafferty WBJ, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S and McMahon SB. Chondroitinase ABC mediated plasticity of spinal sensory function. (2008)
J. Neurosci. 28,11998-12009.

Lidierth M. Long-range projections of Aδ primary afferents in the Lissauer tract of the rat. (2007)
Neuroscience Letters. 425,126-130

Lidierth M. Local and diffuse mechanisms of primary afferent depolarization and pre-synaptic inhibition in the rat spinal cord. (2006)
J. Physiol. 576 309-327

Lidierth M. PULSER: user-friendly, graphical user-interface based software for controlling stimuli during data acquisition with Spike2 for Windows. (2005)
J. Neurosci. Meth. 141: 243-250

Cronin JN, Bradbury EJ & Lidierth M. Laminar distribution of GABAA– and glycine– receptor mediated tonic inhibition in the dorsal horn of the rat lumbar spinal cord: effects of picrotoxin and strychnine on expression of Fos-like immunoreactivity. (2004)
Pain. 112: 156-163.

Wall PD, Lidierth M & Hillman P. Brief and prolonged effects of Lissauer tract stimulation on dorsal horn cells. (1999)
Pain. 83:579-89.

Lidierth M & Wall PD. Dorsal horn cells connected to the lissauer tract and their relation to the dorsal root potential. (1998)
J Neurophysiol. 80:667-79.

Wall PD & Lidierth M. Five sources of a dorsal root potential: their interactions and origins in the superficial dorsal horn. (1997)
J Neurophysiol. 78:860-71.

Lidierth M & Wall PD. Synchronous inherent oscillations of potentials within the lumbar spinal cord. (1996)
Neurosci Lett. 220:25-8.

Lab. Developed Software

Pulser
A versatile GUI based pulse-generator for use during sampling in CED's Spike2 for Windows (Version 5), or Signal (Version 3).

Pulser for Spike2 (Version 1.06a) http://sourceforge.net/projects/sigtool/files/ (Requires Spike2 Version 5 and a 1401plus or later interface)

Pulser for Signal (Version 1.02a) http://sourceforge.net/projects/sigtool/files/ (Requires Signal Version 3 and a Micro1401 MkII or later interface)

MATLAB SON library
Routines for loading/writing/creating Spike2 for Windows files into MATLAB. These are now included in sigTOOL (see below).

Developed to run within MATLAB, sigTOOL provides a programming and analysis environment for processing neuroscience data. A graphical-user interface to this environment provides the end-user with a self-contained application for waveform and spike-train analysis. User-written extensions to this application can be added to the interface on-the-fly without the need to modify any of the existing code. sigTOOL is an open-source package and is free to academic and not-for-profit users. For further details click here.

sigTOOL can be downloaded from the Sourceforge.net web site click here.