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Successes, Diabetes Research Group
Fellowships
PhD Studentships
Prizes and nominations
- Bowe J, King A, Jones PM and Persaud SJ, Down-regulation of islet kisspeptin levels in obesity and pregnancy and stimulatory effects of kisspeptin on insulin secretion. Diabetes UK Basic Science Eli Lilly 2007 poster award
- Barbosa HCL, Bordin S, Persaud SJ, Bowe J, Gagliardino JJ, Boschero AC, Signaling pathways activated by islet neogenesis associated protein in rat islets and MIN6 β-cells. Diabetes UK Basic Science Eli Lilly 2008 poster award
- Muller DS, King A, Liu B, Bowe J, Malicet C, Richardson C, Marsh P, lovanna JL, Jones PM and Persaud SJ, Glucose reciprocally alters p8 and irs2 expression via calcium/calmodulin-dependent kinase IV to regulate R-cell mass. Short-listed for Nick Hales Young Investigator Award, Diabetes UK conference 2008
- Li C, Bowe J, Huang GC, Amiel SA, Jones PM and Persaud SJ, Function of the endocannabinoid system in rodent and human R-cells. Diabetic Medicine 25, A32 short-listed for Nick Hales Young Investigator Award, Diabetes UK conference 2008
- Afshan Malik :Innovation Acceleration award in translational medicine 2008
- King A, 2009 Integrative Pharmacology Fellow Prize for teaching
- Rackham C, Barry S, Jones P, King A . Decline of CD34 positive endothelial cells in islets of langerhans after transplantation. Biochemical Society Young Life Scientists’ Symposia Prize.
- Monica Courtney won the Divisional Postgraduate Research Presentation Prize for her presentation entitled “Generation of insulin-expressing cells from human embryonic stem cells”, which was selected to represent the Division at the School of Biomedical and Health Sciences Postgraduate Open Day in July 2009.
Research Grants
- Bowe: DRWF, "Defining the physiological role of kisspeptin in islet function"
- Christie: JDRF, "Relationship between antibody and T-cell resposes to the 1A-2 autoantigen"
- Christie: EFSD/JDRF/NovoNordisk, "Anti-idiotypic antibodies in the autoimmune response to the 1A-2 autoantigen in type 1 diabetes."
- Clarkin: Diabetes Foundation/Diabetes UK, "Endothelial-endocrine interactions in islets of langerhans"
- Jones and Persaud: NC3Rs, "Pseudoislets as a model system to study β-cell dysfunction in diabetes"
- Jones, Christie & Persaud: Diabetes UK, "Studies of hormone secretion from islets of Langerhans: a multi-detector gamma counter for hormone assay"
- King: NC3Rs, "Reduction of animal use by using a model of islet revascularisation"
- King: Diabetes UK, "Can islets be protected from post tranplantation cell death?"
- King: Friends of Guy's Research Grant, "Can islet transplantation be improved?"
- Malik: South East Development Agency/Johnson and Johnson “ Development of a diagnostic kit for diabetic nephropathy”
- Marsh, Hussain & Jones: Diabetes UK, "Defining the genetic basis of pancreas development in humans: studies of consanguineous children with severe neonatal diabetes"
- Muller: Diabetes UK, "Role of p8 in the regulation of R-cell mass: a potential molecular target for therapy of diabetes"
- Muller: Central Research Fund Equipment Grant, " A study of p8: a potential target for β-cell mass regulation"
- Muller and Persaud: Diabetes UK "Improving β-cell function by modulating Hsp27 and Hsp70 expression"
- Persaud: Diabetes UK, "Autocrine fuel sensing by kisspeptin in pancreatic β-cells"
- Persaud and Jones: European Foundation for the Study of Diabetes, "Role of p8 in β-cell mass expansion and survival"
- Persaud, Hussain, Mills and Eaton: Wellcome Trust "Fasting and protein sensitive hyperinsulinaemic hypoglycaemia due to HADH mutations: understanding novel mechanisms of fatty acid -and amino acid-induced insulin secretion"
Publications 2008
- Barbosa HC, Bordin S, Anhe G, Persaud SJ, Bowe J, Borelli MI, Gagliardino JJ and Boschero, AC (2008) Islet neogenesis associated protein signalling in neonatal pancreatic rat islets: involvement of the cholinergic pathway. J. Endocrinol. (in press)
- Govindarajan G, Vijaykumar M, Rao Ch V, Pushpangadan P, Asare-Anane H, Persaud S, Jones P and Houghton PJ (2008) Antidiabetic activity of Croton klotschionus in rats and direct stimulation of insulin secretion in-vitro. J. Pharm. Pharmacol. 60, 371-376
- Jones PM and Persaud SJ (2008) Human embryonic stem cells: one step closer to curing diabetes. Cellscience Reviews 5, (in press)
- Jones PM, Courtney MJ, Burns CJ and Persaud SJ (2008) Cell-based treatments for diabetes. Drug Discovery Today (in press)
- Persaud SJ, Muller D and Jones PM (2008) Insulin signalling in islets. Biochem. Soc. Trans. 36, 290-293
- Persaud SJ and Jones PM (2008) Beta cell-based therapies for Type 2 diabetes. European Endocrinology (in press)
- Ramracheya RD, Muller D, Squires PE, Brereton H, Sugden D, Huang GC, Amiel SA, Jones PM and Persaud SJ (2008) Function and expression of melatonin receptors on human pancreatic islets. J. Pineal Res. 44, 273-279
- Chen RR, Hussain K, Jones PM and Marsh P (2008) Permanent neonatal diabetes mellitus caused by failure of pancreatic development: report of four more cases and a review of the literature. Pediatrics 121(6):e1541-1547.
- Kitsou-Mylona I, Burns CJ, Squires PE, Persaud SJ and Jones PM (2008) A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans. Cellular Physiology and Biochemistry in press
- King A and Bohman S (2009) Islet α cell number is maintained in microencapsulated islet transplantation. Biochem, Biophys Rec Comm in press
- Stolinski M, Alam S, Jackson NC, Shojaee-Moradie F, Pentecost C, Jefferson W, Christ ER, Jones RH, Umpleby AM. (2008) Effect of 6-month supervised exercise on low-density lipoprotein apolipoprotein B kinetics in patients with type 2 diabetes mellitus. Metabolism. 57(11):1608-14.
Publications 2007
- Brereton H, Luther MJ, Persaud SJ and Jones PM (2007) Islet a-cells do not influence insulin secretion through cell-cell contact. Endocrine 31, 61-65
- Cantley J, Heefron H, Asare-Anane H, Selman C, Lingard S, Choudhury AI, Herrera P, Persaud SJ and Withers DJ (2007) Pancreatic deletion of IRS-2 reduces β-cell mass and impairs glucose homeostasis. Diabetologia 50, 1248-1256
- Carvell M, Marsh P, Persaud SJ and Jones PM (2007) E-cadherin interactions regulate R-cell proliferation in islet-like structures. Cellular Physiology and Biochemistry 20, 617-626
- Govindarajan G, Asare-Anane H, Persaud S, Jones PM and Houghton PJ (2007) Effect of Desmodium gongeticum extract on blood glucose in rats and on insulin secretion in vitro. Planta Medica 73, 427-432
- Jones, PM, Kitsou-Mylona I, Gray E, Squires PE and Persaud SJ (2007) Expression and function of the extracellular calcium-sensing receptor in pancreatic R-cells. Archives of Physiology & Biochemistry 113, 98-103
- Muller D. Huang GC, Amiel S, Jones PM and Persaud SJ (2007) Gene expression heterogeneity in human islet endocrine cells: the insulin signalling cascade. Diabetologia 50, 1239-1242
- Papadimitriou A, King A, Jones PM and Persaud SJ (2007) Anti-apoptotic effects of arachidonic acid and prostaglandin EZ in pancreatic R-cells. Cellular Physiology and Biochemistry 20, 607-616
- Persaud SJ., Belin VD, Muller D, Asare-Anane H, Kitsou-Mylona I, Papadimitriou A, Burns CJ, Huang GC, Amiel SA and Jones PM (2007) The role of arachidonic acid and its metabolites in insulin secretion from human islets of Langerhans. Diabetes 56, 197-203
- Persaud SJ, Muller D, Belin VD, Papadimitriou A, Huang GC, Amiel SA and Jones PM (2007) Expression and function of cyclooxygenase and lipoxygenase enzymes in human islets of Langerhans. Archives of Physiology & Biochemistry 113, 104-109
- Richardson CC, Jones PM, Persaud SJ, Clark A, Hussain K and Christie MR (2007) Low levels of glucose transporter and K-ATP channel expression in pancreatic beta cells early in development. Diabetologia 50, 1000-1005
- Wu Y, Minger SL, Sawyer GJ, Fabre JW, Persaud SJ and Jones PM (2007) PDX-1 expression is insufficient to trans-differentiate liver cells into insulin secreting cells. Pancreas 34, 272-275
- Zhao M, Muiesan P, Amiel SA, Srinivasan P, Asare-Anane H, Fairbanks L, Persaud S, Jones P, Jones J, Ashraf S, Littlejohn W, Rela M, Heaton N and Huang GC (2007) Human islets derived from donors after cardiac death are fully biofunctional. Am. J. Transplantation 7, 2318-2325
- Malik AN, Christos Rossios, Ghada Al-Kafaji, and Rachel A. Page “Glucose regulation of CDK7, a putative thiol related gene, in experimental diabetic nephropathy” Biochem. Biophys. Res. Comm. 357:237-244 (2007)
- Malik AN, Ghada Al-Kafaji “Glucose-regulation of Beta-defensin-1 mRNA in human renal cells” Biochem. Biophys. Res. Comm. 353:318-323 (2007)
Publications 2009
- Malik AN, Rojeen Shahni and Masud Iqbal “Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy” Diabetes Research and Clinical Practice, in press (2009)
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