Department of Medical and Molecular Genetics
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The Department of Medical and Molecular Genetics aims to identify genes, their functions, and variants, implicated in both Mendelian and complex common disorders. Recent studies have focussed on aspects of breast cancer development, susceptibility to inflammatory bowel disease and psoriasis and molecular characterisation of the pathogenesis of the vascular disorder known as pulmonary arterial hypertension.
Further substantial research programmes exist in neurogenetics including basic to translational aspects of Huntington disease, while other work explores epigenetic effects (eg imprinting and control of gene expression, and epistatic interactions between genes). A number of groups are involved in development of statistical approaches to whole genome association studies and the integration of emerging biological databases with genomic studies.
Further substantial research programmes exist in neurogenetics including basic to translational aspects of Huntington disease, while other work explores epigenetic effects (eg imprinting and control of gene expression, and epistatic interactions between genes). A number of groups are involved in development of statistical approaches to whole genome association studies and the integration of emerging biological databases with genomic studies.