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Translational Cancer Medicine MRes

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Overview

Translational Cancer Medicine enables you to gain detailed knowledge and understanding of research methods applied to rational drug design, clinical study design, molecular and cell biology, tumour immunology, genetics and cancer imaging. Practical experience gained through two six-month laboratory rotations.

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Key benefits

  • The range of topics including advanced imaging methods is unique for this translational cancer programme

  • The sponsoring laboratories and departments all have international standing and have agreed to closely supervise the trainees

  • Recently released data from the Higher Education Funding Council for England (Hefce) shows that King’s College London is equal top in England (with Queen Mary, University of London) for its PhD completion rates. This programme will potentially select candidates for the PhD programme within the Division of Cancer Studies


Key information

Application status Open

Duration One year FT, September to September; two year PT option available to Medics working in London

Study mode Full-time, Part-time

Credit value UK 180/ECTS 90

Course intake 8-12 FT

Course leaders Prof Tony Ng, Programme Director

Course contact for further information For admissions queries please telephone +44 (0)20 7848 1649

Course contact email dora.jonsdottir@kcl.ac.uk

Awarding institution King's College London

Faculty Faculty of Life Sciences & Medicine

Department

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Entry requirements & how to apply


Visit our admissions webpages to view our English language entry requirements.

First class or high 2:1 BSc (honours) degree or overseas equivalent in biomolecular or physical sciences. MBBS students can be admitted at any time following the third year of their programme. Post-year three: entry is based on year three performance plus evidence of knowledge of the basic elements of translational research topics. Advanced years (four to five): students must complete their current year of study. External students need to obtain permission from their own medical school and provide evidence of their exam performance in the pre-clinical examinations.

Application procedure

Applications are made on-line. To apply, please select the 'Apply' button at the top right of this page.

Personal statement and supporting information

Please detail your research experience and any previous laboratory experience. Include your reason for applying and career aims. Please specify two areas of interest from the list of projects in the description. MBBS students should provide a statement demonstrating knowledge of basic elements of translational research topics such as epidemiology, clinical biostatistics and clinical pharmacology (relating to drug discovery).

Application closing date

The deadline for applications is 01 April 2016 for 2016 entry. Prior to this date all applications will be given equal consideration and considered on their individual merits. After this date applications will be considered subject to the availability of places, thus we encourage you to submit your application as soon as possible. Please note that funding deadlines may be earlier.

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Course detail

Description

Overview of subjects covered:

  • Biomarkers, Biostatistics and Modelling
  • Breast Cancer
  • Cancer Bioinformatics
  • Cancer Imaging (Optical)
  • Cancer Imaging (PET)
  • Cancer Surgery
  • Clinical Trials and translational research
  • Gene discovery through to therapeutic applications
  • Haemato-oncology and associated genetics/genomics
  • Immunology of Cancers
  • Molecular Pathology
  • Signal Transduction in cancers.

Project titles 2016-2017:

  • Dr Van Hemelrijck: Serum biomarkers and risk of cancer in the Swedish AMORIS dataset - data on 800,000 men and women
  • Prof Ridley: Targeting Rho signalling networks in cancer invasion and metastasis
  • Dr Arnold: Tumour associated macrophages
  • Dr Carlton: Regulation of cell division and receptor degradation by the ESCRT-machinery 
  • Dr Fruhwirth: Metabolomics as a biomarker for breast cancer progression
  • Dr Irshad: Molecular profiling of post chemotherapy residual disease in triple negative breast cancers
  • Prof Ng: cMet/ErbB and exosomes in non-small cell lung cancer
  • Prof Watt: Impact of impaired Notch signalling in oral squamous cell carcinoma
  • Prof Tavassoli: Predictive Biomarkers of Treatment Resistance in Head and Neck Squamous Cell Carcinoma
  • Dr Ciccarelli: Validation of cancer-specific synthetic lethality
  • Prof Farzaneh: High throughput analysis of modulators of cellular immunity against cancer associated antigens
  • Dr Chan, Dr Maher & Dr Harrison: Development of novel chimeric antigen receptor (CAR) based cytotoxic cells
  • Prof Ghulam Mufti: Mutational landscape in MDS & AML
  • Dr Buggins & Dr Patten: A novel circulation system to investigate lymphoid migration in low grade lymphoma
  • Dr Ramsay: Investigating the tumour microenvironment (TME) and immune suppression in lymphoma
  • Prof Dazzi: Searching for the inflammatory cues contributing to tumour cell protection in the niche
  • Prof Goh & Prof Cook: Optimising multimodality treatment response assessment with imaging
  • Prof McGurk & Dr Schilling: Development of intraoperative navigation for Sentinel Node Biopsy detection in early cancer
  • Prof McGurk, Dr Schilling & Dr Coward: Use of 3D modelling for planning cancer surgery
  • Prof McGurk, Dr Schilling & Dr Di Silvio: Diagnosis, evaluation and treatment of Osteoradionecrosis (ORN) affected tissue following radiotherapy 
  • Dr Sarker & Dr Spicer: Factors affecting patient recruitment and experience in Phase 1 trials
  • Dr Maher: Genetic targeting of T-cells against cancer
  • Dr Sawyer: Identification of genes that predispose to lobular breast cancer
  • Dr Grigoriadis & Dr Marra: Exploring genomic instability in Triple-Negative Breast Cancers
  • Dr Karagiannis & Dr Spicer: Antibody drug discovery and development for cancer
  • Prof Burchell: Changes in post-translational modifications (O-linked glycosylation) of breast cancer: The effect on tumour behaviour and immune recognition
  • Prof Ng: Investigation of the role of B regulatory cells in anti-tumour immunity within breast cancers

Course purpose

The programme will provide students with a detailed knowledge and understanding of research methods applied to rational drug design, clinical study design, molecular and cell biology, tumour immunology, genetics and cancer imaging, all of which are relevant to Translational Cancer Research. In addition, practical experience will be gained through two laboratory rotations of six months duration.

Course format and assessment

Work with 2 supervisors and their teams, 6 months in each lab

Assignments:

• 30 credit taught module:

2-3 weekly lectures during first 3 months

Throughout the year, students also attend literature reviews and journal clubs that their labs/departments organise and any other internal or external seminars deemed relevant to their projects/assignments.

The assessment for this module is an essay on the fundamentals and the overall concept of Translational Cancer Medicine

• 75 credit laboratory based research project 1:

Assessed by a written dissertation, a seminar presentation and an oral examination

• 75 credit laboratory based research project 2:

Assessed by a draft of a paper of the standard and format required by a scientific journal.

Extra information

Occupational health clearance will be required for some of the projects.

Structure

  • Required Modules

    30 credit taught module:
    2-3 weekly lectures during first 3 months
    Throughout the year, students also attend literature reviews and journal clubs that their labs/departments organise and any other internal or external seminars deemed relevant to their projects/assignments.
    The assessment for this module is an essay on the fundamentals and the overall concept of Translational Cancer Medicine

    75 credit laboratory based research project 1:
    Assessed by a written dissertation, a seminar presentation and an oral examination

    75 credit laboratory based research project 2:
    Assessed by a draft of a paper of the standard and format required by a scientific journal.

    Students are also invited to attend a week-long workshop in Bioinformatics and Epidemiology. This provides a conceptual framework as well as a methodological introduction to the integrated use of epidemiology and bioinformatics approaches in modern translational research.

    Fundamentals Of Translational Cancer Medicine
    Translational Cancer Medicine Laboratory Rotation 1
    Translational Cancer Medicine Laboratory Rotation 2
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Career prospects

Future PhD studies. Clinical and non-clinical academic careers in cancer medicine.

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Fees and funding

Full time tuition fees - Home/EU

£10,500 p.a. (2016/17)*

Full time tuition fees - Overseas

£23,400 p.a. (2016/17)*

Part time tuition fees - Home/EU

£5,250 p.a. (2016/17)*

Part time tuition Fees - Overseas

£11,700 p.a. (2016/17)*

*This tuition fee is subject to annual increases.

Please visit our web pages on fees and funding for more information.

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