Dr Jeremy Carlton
In 2015, the Crick and its university partners ran its pilot recruitment drive to select the first cohort of researchers to move to the new Crick research facilities. Dr Jeremy Carlton was one of the five group leaders selected and he will be moving to the new Crick research facilities in the summer of 2016, taking his place as one of the first residents of what will be the largest biomedical research facility in Europe.
“I’m looking forward to moving to the new Crick facilities and engaging with researchers from other London universities, and interacting with basic scientists, like myself, that work in a range of different disciplines,” he says. Moving his lab from King’s to the Crick will pose challenges, but the exposure to the wider community of researchers and leaders in their fields, is what is most exciting to him. As the Crick moves closer to fulfilling the reality of its philosophy to foster collaborative research, to better understand disease and to find new ways to diagnose, treat and prevent illnesses, Jeremy is ready to be a pioneer of a new paradigm.
Understanding membrane remodelling during cell division
As a basic scientist, Jeremy is interested in the basic biology of cells in the human body. His current research is focused on the cell’s internal membranes and how they are shaped and distributed during cell division (mitosis). He is trying to understand how the nuclear envelope (or the nuclear membrane) is broken down at the start of mitosis, how components of the envelope are separated into daughter cells, and how these components are rebuilt as mitosis progresses. Mitosis is essential for growth and development and understanding the basic mechanisms underlying mitotic biology provides a deeper understanding of the deregulation of cell division in disease.
Working at the Crick
Jeremy’s lab uses molecular biology, biochemical and advanced imaging techniques to conduct his investigations. At the Crick, Jeremy will be working with Lucy Collinson and the Electron Microscopy facilities. Access to these facilities and the expertise of Lucy will help to achieve high-resolution images, which will give him a more detailed view of the mitotic processes in cells. He also has a deep interest in Frank Uhlmann’s research into the mechanisms that control the fidelity of cell division. Jeremy hopes that access to Frank’s lab and expertise will give him a better understanding of the processes involved in cell division and the communication that occurs when cells need to halt division when they encounter problems during mitosis.
However, it is more than the shared resources and expertise at the Crick that is of interest to Jeremy. Being a part of a large and thriving community of researchers with similar research interests will enable him to share ideas, discoveries and techniques, and it is the potential of this kind of collaborative culture that he feels is the greatest value of the Crick.
“The quality of the science and the scientists at the Crick will be very exciting for opening our minds,” he says.
Being one of the first cohort of researchers to take residence in the new building gives him the opportunity to become involved at the outset of this collaborative culture. The common community at the Crick, fed by the London partners, provides a great facilitation for interaction between scientists. Making new associations whilst still maintaining engagement with King’s gives him the ability to help build these bridges. As one of the university staff “attachments” to the Crick, Jeremy provides a critical link between King’s and the Crick, helping to foster a more inclusive and collaborative network of scientists in London.
Jeremy will be in his new lab at the Francis Crick Institution research facility by the end of the year, when he will truly begin to reap the benefits of the partnership.