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Andoniadou Lab

Research Projects


Heavner WE, Andoniadou CL, Pevny LH. Establishment of the neurogenic boundary of the mouse retina requires co-operation of SOX2 and WNT signalling. Neural Dev. 2014 Dec 9;9:27. doi: 10.1186/1749-8104-9-27. PMID: 25488119

Gregory LC, Gaston-Massuet C, Andoniadou CL, Carreno G, Webb EA, Kelberman D, McCabe MJ, Panagiotakopoulos L, Saldanha JW, Spoudeas HA, Torpiano J, Rossi M, Raine J, Canham N, Martinez-Barbera JP, Dattani MT. The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism. Clin Endocrinol (Oxf). 2015 May;82(5):728-38. doi: 10.1111/cen.12637. Epub 2014 Dec 9. PMID: 25327282

Jones KM, Sarić N, Russell JP, Andoniadou CL, Scambler PJ, Basson MA. CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus. Stem Cells. 2015 Jan;33(1):196-210. doi: 10.1002/stem.1822. PMID: 25183173

Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny LH, Martinez-Barbera JP. Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumour-inducing potential. Cell Stem Cell. 2013 Oct 3;13(4):433-45. doi: 10.1016/j.stem.2013.07.004. PMID: 24094324

Webb EA, AlMutair A, Kelberman D, Bacchelli C, Chanudet E, Lescai F, Andoniadou CL, Banyan A, Alsawaid A, Alrifai MT, Alahmesh MA, Balwi M, Mousavy-Gharavy SN, Lukovic B, Burke D, McCabe MJ, Kasia T, Kleta R, Stupka E, Beales PL, Thompson DA, Chong WK, Alkuraya FS, Martinez-Barbera JP, Sowden JC, Dattani MT. ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies. Brain. 2013 Oct;136(Pt 10):3096-105. doi: 10.1093/brain/awt218. Epub 2013 Sep 10. PMID: 24022475

Andoniadou CL, Martinez-Barbera JP. Developmental mechanisms directing early anterior forebrain specification in vertebrates. Cell Mol Life Sci. 2013 Oct;70(20):3739-52. doi: 10.1007/s00018-013-1269-5. Epub 2013 Feb 9. Review. PMID: 23397132

Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP. SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct;122(10):3635-46. doi: 10.1172/JCI64311. Epub 2012 Sep 4. PMID: 22945632

Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT, Martinez-Barbera JP. Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol. 2012 Aug;124(2):259-71. doi: 10.1007/s00401-012-0957-9. Epub 2012 Feb 18. PMID: 22349813

Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP. HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. Development. 2011 Nov;138(22):4931-42. doi: 10.1242/dev.066597. Epub 2011 Oct 17. PMID: 22007134

Alatzoglou KS, Andoniadou CL, Kelberman D, Buchanan CR, Crolla J, Arriazu MC, Roubicek M, Moncet D, Martinez-Barbera JP, Dattani MT. SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours. Hum Mutat. 2011 Dec;32(12):1376-80. doi: 10.1002/humu.21606. Epub 2011 Oct 11. PMID: 21919124

Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP. Increased Wingless (Wnt) signalling in pituitary progenitor/stem cells gives rise to pituitary tumours in mice and humans. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11482-7. doi: 10.1073/pnas.1101553108. Epub 2011 Jun 2. PMID: 21636786

Remboutsika E, Elkouris M, Iulianella A, Andoniadou CL, Poulou M, Mitsiadis TA, Trainor PA, Lovell-Badge R. Flexibility of neural stem cells. Front Physiol. 2011 Apr 11;2:16. doi: 10.3389/fphys.2011.00016. eCollection 2011. PMID: 21516249

Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP. Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech. 2008 Nov-Dec;1(4-5):241-54. doi: 10.1242/dmm.000711. Epub 2008 Nov 6. PMID: 19093031

Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JM, Martinez-Barbera JP. Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol. 2008 Dec 15;324(2):322-33. doi: 10.1016/j.ydbio.2008.08.008. Epub 2008 Aug 18. PMID: 18775421

Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M, Martinez-Barbera JP. DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim Biophys Acta. 2008 Jan;1783(1):131-43. Epub 2007 Sep 7. PMID: 17931718

Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP. Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508. Epub 2007 Mar 14. PMID: 17360769

Xavier GM, Patist AL, Healy C, Pagrut A, Carreno G, Sharpe PT, Martinez-Barbera JP, Thavaraj S, Cobourne MT, Andoniadou CL. Activated WNT signalling in postnatal SOX2-positive dental stem cells can drive odontoma formationScientific Reports. 2015 In press, DOI: 10.1038/srep14479



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