Located on the 27th floor of the Tower Wing at Guy's Hospital, London Bridge, the Craniofacial Development & Stem Cell Biology Division of the Faculty of Dentistry, Oral & Craniofacial Sciences is equipped with four laboratories and state of the art facilities. Within our division, we have the following research groups:
Andoniadou Lab is interested in the intrinsic and extrinsic signalling mechanisms that regulate the progenitor/stem cell pool and control cell fate decisions.
The Basson Lab studies the function of signalling regulators and chromatin remodelling factors in development in order to uncover the mechanisms underlying congenital disease. The group is primarily interested in neurodevelopmental conditions.
The Chiappini Lab or the Nanomaterials and Biointerfaces lab is a research group led by Dr. Ciro Chiappini in the Department of Craniofacial Development and Stem Cell Biology. The mission of the lab is to blend nanotechnology, bioengineering and cell biology to develop functional materials that direct cell behaviour
The Cobourne Lab is primarily focussed on further understanding Hedgehog signalling during early craniofacial development. We also maintain an active clinical research group investigating evidence-based orthodontics.
Francis-West Lab studies the function of Dchs1-Fat4-PCP and Hippo signalling during development. The group is currently focused on the development of the craniofacial complex, branching morphogenesis and neuronal migrations.
Gentleman Lab develops innovative biomaterials to control stem cell differentiation for regenerative medicine.
Green Lab investigates spatial aspects of embryonic development, specifically the action of morphogens and tissue morphogenesis.
Knight Lab aim to understand the molecular and cellular events that direct stem cells during musculoskeletal development and regeneration.
Miletich Lab studies the biology of salivary gland stem cells in order to provide new treatment options for patients affected with dry mouth caused by irreversible salivary gland dysfunction.
Sharpe Lab studies teeth as a model system to explore the basic processes of developmental pattern formation, stem cell biology and tissue repair and regeneration.
Streit Lab investigates the integration of signalling pathways, epigenetic changes and transcription factor networks during cell fate decisions
Tucker Lab is interested in development of the head, with particular focus on structures that form in association with the jaw.