Principal Investigator: Dr Karen Liu
The Liu Lab studies the development of the neural crest lineage from induction and migration to differentiation. Neural crest cells are a fascinating migratory cell population that gives rise to all kinds of tissues, such as the bone and cartilage in the head, melanocytes and sensory systems. A recent focus has been on cilia in the neural crest. Patients with ciliopathies frequently have neural crest-associated craniofacial anomalies and we model these anomalies using animal models (mouse, frog, chicken) and human-induced pluripotent stem cells. A second major interest in the lab is signal transduction in the neural crest, with a focus on glycogen synthase kinase-3 (GSK-3) and Wnt signalling.
Tel: +44 (0)207 188 8035