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Naglik Lab

Naglik Lab

Research in the Naglik Laboratory relates to host-microbial interactions at mucosal surfaces with specific emphasis on fungal and bacterial pathogenesis, mucosal immunity and epithelial signalling. My group has identified epithelial mechanisms that discriminate between the commensal and pathogenic state of the human fungal pathogen Candida albicans and has recently identified a cytolytic peptide toxin (Candidalysin) that activates this discriminatory mechanism. Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen and reveals the mechanism by which C. albicans damages and activates epithelial tissues. Current research projects relate to determining the structure of Candidalysin in epithelial membranes and the mechanism of mucosal immune induction. Other projects relate to identifying how periodontal pathogens activate epithelial tissues. Our work is funded by the Medical Research Council, Biotechnology and Biological Sciences Research Council, The Wellcome Trust and The European Union.

 

Key collaborators (KCL):

Mahvash Tavassoli/Selvam Thavaraj (Oral Cancer)

Gavin Bewick (Diabetes)

James Mason (Pharmaceutical Sciences Institute)

Antoni Borysik (Chemistry)

Jon Robbins (Neuroscience)

David Moyes (Host-Microbiome Interactions)
 
 
Key collaborators (UK):
 

Ernesto Cota (Imperial College London) 

Darius Armstrong-James (Imperial College London)

Elaine Bignell (University of Manchester)

Stefan Howorka (University College London)

Gordon Ramage (University of Glasgow)

Craig Murdoch (University of Sheffield)

Marisa Martin-Fernandez/Stan Botchway (Research Complex, Harwell)

Elizabeth Johnson (Mycology Reference Laboratory, Bristol)

Dek Woolfson (Bristol University)
 
 
Key collaborators (Europe):
 

Gary Moran (Trinity College Dublin, Ireland)

Bernhard Hube (Hans Knoell Insitute, Jena, Germany)

Oliver Bader (University of Gottingen, Germany)

Thomas Gutsmann (Borstel, Germany)

Martin Schaller (University of Tuebingen, Germany)

Jurgen Ruland (Munich University, Germany)

Kai Sohn (Stuttgart University, Germany)

Concha Gil (University of Madrid, Spain)

Toni Gabaldon (Centre for Genomic Regulation, Barcelona, Spain)

Constantin Urban (Umea University, Sweden)

Robert Vacha (Prague University, Czech Republic)
 
 
Key collaborators (US/other):
 

Sarah Gaffen (University of Pittsburgh, USA)

Dan Kaplan (University of Pittsburgh, USA)

Robert Wheeler (University of Maine, USA)

Brian Peters (University of Tennessee, USA)

Paul Fidel/Mairi Noverr (Louisiana State University, USA)

Scott Filler (UCLA, USA)

Bruce Klein (University of Wisconsin, USA)

Aaron Weinberg (Case Western Reserve, USA)

Ken Ishii (National Institute of Biomedical Innovation, Japan)

 

Contact Information 

Email: julian.naglik@kcl.ac.uk 

Tel: +44 (0)20 7848 6123  

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