Saliva- based Raman spectroscopy for early detection of oral and systemic cancers
Project details
First supervisor: Dr Mads S Bergholt
Mode of study: Full-time
Eligibility: UK / Overseas
Start dates: 01 October, 01 February, 01 June
Application deadline: Open until a suitable candidate is found
Reference number: 2026-MSB
Open to externally sponsored or self-funded applicants
See Fees or Funding for current rates
Contact supervisor for expected bench fee rates
Project description
This PhD project proposes a non-invasive diagnostic platform using Raman spectroscopy to identify early biochemical signatures of cancer in saliva, with a focus on oral cancer and broader systemic malignancies such as lung cancer and breast cancer. By integrating surface-enhanced Raman spectroscopy (SERS) with advanced machine learning techniques, the study aims to detect subtle molecular changes, including altered protein structures, nucleic acid content, and metabolic byproducts associated with tumour development. Saliva samples will be collected from both healthy individuals and diagnosed patients, followed by spectral acquisition and data-driven classification modelling. This approach offers a rapid, cost-effective, and easily deployable alternative to conventional screening methods, which are often invasive or resource-intensive. The ultimate goal is to develop a portable diagnostic tool capable of early-stage cancer detection, improving survival rates and enabling widespread screening in both clinical and low-resource settings.
Research training
Students will learn skill sets which include Raman spectroscopy, nanotechnology, and AI
Next steps
In the first instance, please contact the supervisor to discuss your interest in the project prior to submitting an application.
To view entry requirements and further general information, see the Dental and Health Sciences Research MPhil/PhD prospectus page.
Apply online at apply.kcl.ac.uk following these steps:
- Register a new account/login.
- Once logged in, select Create a new application.
- Enter ‘Dental and Health Sciences Research MPhil/PhD (Full-time)' under Choose a Programme.
- Select your chosen start date.
- Please note: Applicants must include the project reference number (2026-MSB) in the 'Research proposal' and 'Funding (point 5)' sections of the application
Contact for further information
Related Centre: Centre for Craniofacial & Regenerative Biology
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