Phenotyping living cardiomyocytes with light
12 February 2019, 13:00 to 14:00 Please note: this event has passed
Guy’s Campus, London
Phenotyping living cardiomyocytes with light.
Speaker: Dr Matthew Daniels, Radcliffe Department of Medicine, University of Oxford
Host: Luca Fusi
Abstract: We lack the ability to study cardiomyocyte form (sarcomere spacing, orientation, density) and function (calcium, voltage, force) in living cells. This is especially true of the amorphous IPS derivative at single cell scale. I will show how, and explain why existing dye based approaches cannot be considered suitable partners in studies of contractility. Instead, we make proteins to reveal IPS-CM form and function in real-time, in the absence of contractile impairment, and in combination with quantitative force measurement, even when buried in the myofilament itself.
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